› › Function and Biology

Crystal structure of dimethylglycine oxidase of Arthrobacter globiformis in complex with folic acid

Source organism: Arthrobacter globiformis
Biochemical function: dimethylglycine oxidase activity
Biological process: not assigned
Cellular component: not assigned

Quick links

EC 1.5.3.10: Dimethylglycine oxidase

Reaction catalysed:
N,N-dimethylglycine + H(2)O + O(2) = sarcosine + formaldehyde + H(2)O(2)
Systematic name:
N,N-dimethylglycine:oxygen oxidoreductase (demethylating)

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF08669
Domain description: Glycine cleavage T-protein C-terminal barrel domain
Occurring in:
  1. Dimethylglycine oxidase
The deposited structure of PDB entry 1pj6 contains 1 copy of Pfam domain PF08669 (Glycine cleavage T-protein C-terminal barrel domain) in Dimethylglycine oxidase. Showing 1 copy in chain A.

PF01571
Domain description: Aminomethyltransferase folate-binding domain
Occurring in:
  1. Dimethylglycine oxidase
The deposited structure of PDB entry 1pj6 contains 1 copy of Pfam domain PF01571 (Aminomethyltransferase folate-binding domain) in Dimethylglycine oxidase. Showing 1 copy in chain A.

PF16350
Domain description: FAD dependent oxidoreductase central domain
Occurring in:
  1. Dimethylglycine oxidase
The deposited structure of PDB entry 1pj6 contains 1 copy of Pfam domain PF16350 (FAD dependent oxidoreductase central domain) in Dimethylglycine oxidase. Showing 1 copy in chain A.

PF01266
Domain description: FAD dependent oxidoreductase
Occurring in:
  1. Dimethylglycine oxidase
The deposited structure of PDB entry 1pj6 contains 1 copy of Pfam domain PF01266 (FAD dependent oxidoreductase) in Dimethylglycine oxidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036188
Domain description: FAD/NAD(P)-binding domain superfamily
Occurring in:
  1. Dimethylglycine oxidase
IPR029043
Domain description: Glycine cleavage T-protein/YgfZ, C-terminal
Occurring in:
  1. Dimethylglycine oxidase
IPR013977
Domain description: Glycine cleavage T-protein, C-terminal barrel domain
Occurring in:
  1. Dimethylglycine oxidase
IPR006222
Domain description: Aminomethyltransferase, folate-binding domain
Occurring in:
  1. Dimethylglycine oxidase
IPR027266
Domain description: GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1
Occurring in:
  1. Dimethylglycine oxidase
IPR032503
Domain description: FAD dependent oxidoreductase, central domain
Occurring in:
  1. Dimethylglycine oxidase
IPR028896
Domain description: Aminomethyltransferase-like
Occurring in:
  1. Dimethylglycine oxidase
IPR006076
Domain description: FAD dependent oxidoreductase
Occurring in:
  1. Dimethylglycine oxidase

Structure domains

CATH CATH domains
3.50.50.60
Class: Alpha Beta
Architecture: 3-Layer(bba) Sandwich
Topology: FAD/NAD(P)-binding domain
Homology: FAD/NAD(P)-binding domain
Occurring in:
  1. Dimethylglycine oxidase
The deposited structure of PDB entry 1pj6 contains 1 copy of CATH domain 3.50.50.60 (FAD/NAD(P)-binding domain) in Dimethylglycine oxidase. Showing 1 copy in chain A.
3.30.70.1400
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Aminomethyltransferase beta-barrel domains
Occurring in:
  1. Dimethylglycine oxidase
The deposited structure of PDB entry 1pj6 contains 1 copy of CATH domain 3.30.70.1400 (Alpha-Beta Plaits) in Dimethylglycine oxidase. Showing 1 copy in chain A.
3.30.1360.120
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Gyrase A; domain 2
Homology: Probable tRNA modification gtpase trme; domain 1
Occurring in:
  1. Dimethylglycine oxidase
The deposited structure of PDB entry 1pj6 contains 1 copy of CATH domain 3.30.1360.120 (Gyrase A; domain 2) in Dimethylglycine oxidase. Showing 1 copy in chain A.
3.30.9.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: D-Amino Acid Oxidase; Chain A, domain 2
Homology: D-Amino Acid Oxidase, subunit A, domain 2
Occurring in:
  1. Dimethylglycine oxidase
The deposited structure of PDB entry 1pj6 contains 1 copy of CATH domain 3.30.9.10 (D-Amino Acid Oxidase; Chain A, domain 2) in Dimethylglycine oxidase. Showing 1 copy in chain A.
2.40.30.110
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Elongation Factor Tu (Ef-tu); domain 3
Homology: Aminomethyltransferase beta-barrel domains
Occurring in:
  1. Dimethylglycine oxidase
The deposited structure of PDB entry 1pj6 contains 1 copy of CATH domain 2.40.30.110 (Elongation Factor Tu (Ef-tu); domain 3) in Dimethylglycine oxidase. Showing 1 copy in chain A.
SCOP SCOP annotations
51913
Class: Alpha and beta proteins (a/b)
Fold: FAD/NAD(P)-binding domain
Superfamily: FAD/NAD(P)-binding domain
Occurring in:
  1. Dimethylglycine oxidase
The deposited structure of PDB entry 1pj6 contains 1 copy of SCOP domain 51913 (FAD-linked reductases, N-terminal domain) in Dimethylglycine oxidase. Showing 1 copy in chain A.
101791
Class: All beta proteins
Fold: Elongation factor/aminomethyltransferase common domain
Superfamily: Aminomethyltransferase beta-barrel domain
Occurring in:
  1. Dimethylglycine oxidase
The deposited structure of PDB entry 1pj6 contains 1 copy of SCOP domain 101791 (Aminomethyltransferase beta-barrel domain) in Dimethylglycine oxidase. Showing 1 copy in chain A.
103026
Class: Alpha and beta proteins (a+b)
Fold: Folate-binding domain
Superfamily: Folate-binding domain
Occurring in:
  1. Dimethylglycine oxidase
The deposited structure of PDB entry 1pj6 contains 1 copy of SCOP domain 103026 (Aminomethyltransferase folate-binding domain) in Dimethylglycine oxidase. Showing 1 copy in chain A.
54394
Class: Alpha and beta proteins (a+b)
Fold: FAD-linked reductases, C-terminal domain
Superfamily: FAD-linked reductases, C-terminal domain
Occurring in:
  1. Dimethylglycine oxidase
The deposited structure of PDB entry 1pj6 contains 1 copy of SCOP domain 54394 (L-aminoacid/polyamine oxidase) in Dimethylglycine oxidase. Showing 1 copy in chain A.

Quick links