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PYRUVATE KINASE FROM E. COLI IN THE T-STATE

Source organism: Escherichia coli
Biochemical function: metal ion binding
Biological process: phosphorylation
Cellular component: pyruvate kinase complex

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EC 2.7.1.40: Pyruvate kinase

Reaction catalysed:
ATP + pyruvate = ADP + phosphoenolpyruvate
Systematic name:
ATP:pyruvate 2-O-phosphotransferase
Alternative Name(s):
  • Phosphoenol transphosphorylase
  • Phosphoenolpyruvate kinase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02887
Domain description: Pyruvate kinase, alpha/beta domain
Occurring in:
  1. Pyruvate kinase I
The deposited structure of PDB entry 1pky contains 4 copies of Pfam domain PF02887 (Pyruvate kinase, alpha/beta domain) in Pyruvate kinase I. Showing 1 copy in chain A.

PF00224
Domain description: Pyruvate kinase, barrel domain
Occurring in:
  1. Pyruvate kinase I
The deposited structure of PDB entry 1pky contains 4 copies of Pfam domain PF00224 (Pyruvate kinase, barrel domain) in Pyruvate kinase I. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001697
Domain description: Pyruvate kinase
Occurring in:
  1. Pyruvate kinase I
IPR036918
Domain description: Pyruvate kinase, C-terminal domain superfamily
Occurring in:
  1. Pyruvate kinase I
IPR015795
Domain description: Pyruvate kinase, C-terminal
Occurring in:
  1. Pyruvate kinase I
IPR018209
Domain description: Pyruvate kinase, active site
Occurring in:
  1. Pyruvate kinase I
IPR015806
Domain description: Pyruvate kinase, insert domain superfamily
Occurring in:
  1. Pyruvate kinase I
IPR011037
Domain description: Pyruvate kinase-like, insert domain superfamily
Occurring in:
  1. Pyruvate kinase I
IPR040442
Domain description: Pyruvate kinase-like domain superfamily
Occurring in:
  1. Pyruvate kinase I
IPR015813
Domain description: Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily
Occurring in:
  1. Pyruvate kinase I
IPR015793
Domain description: Pyruvate kinase, barrel
Occurring in:
  1. Pyruvate kinase I

Structure domains

CATH CATH domains
3.20.20.60
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Phosphoenolpyruvate-binding domains
Occurring in:
  1. Pyruvate kinase I
The deposited structure of PDB entry 1pky contains 4 copies of CATH domain 3.20.20.60 (TIM Barrel) in Pyruvate kinase I. Showing 1 copy in chain A.
3.40.1380.20
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Pyruvate Kinase; Chain: A, domain 1
Homology: Pyruvate kinase, C-terminal domain
Occurring in:
  1. Pyruvate kinase I
The deposited structure of PDB entry 1pky contains 4 copies of CATH domain 3.40.1380.20 (Pyruvate Kinase; Chain: A, domain 1) in Pyruvate kinase I. Showing 1 copy in chain A.
2.40.33.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: M1 Pyruvate Kinase; Domain 3
Homology: PK beta-barrel domain-like
Occurring in:
  1. Pyruvate kinase I
The deposited structure of PDB entry 1pky contains 4 copies of CATH domain 2.40.33.10 (M1 Pyruvate Kinase; Domain 3) in Pyruvate kinase I. Showing 1 copy in chain A.
SCOP SCOP annotations
51622
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: Phosphoenolpyruvate/pyruvate domain
Occurring in:
  1. Pyruvate kinase I
The deposited structure of PDB entry 1pky contains 4 copies of SCOP domain 51622 (Pyruvate kinase) in Pyruvate kinase I. Showing 1 copy in chain A.
52936
Class: Alpha and beta proteins (a/b)
Fold: Pyruvate kinase C-terminal domain-like
Superfamily: PK C-terminal domain-like
Occurring in:
  1. Pyruvate kinase I
The deposited structure of PDB entry 1pky contains 4 copies of SCOP domain 52936 (Pyruvate kinase, C-terminal domain) in Pyruvate kinase I. Showing 1 copy in chain A.
50801
Class: All beta proteins
Fold: PK beta-barrel domain-like
Superfamily: PK beta-barrel domain-like
Occurring in:
  1. Pyruvate kinase I
The deposited structure of PDB entry 1pky contains 4 copies of SCOP domain 50801 (Pyruvate kinase beta-barrel domain) in Pyruvate kinase I. Showing 1 copy in chain A.

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