EC 2.7.11.22: Cyclin-dependent kinase
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:cyclin phosphotransferase
Alternative Name(s):
- Bur1
- Bur1 Cdk
- CDK
- Cak1
- Cak1p
- Cdc2
- Cdc2 kinase
- Cdc28p
- Cdk-activating kinase
- Cdk-activating protein kinase
- Cdk1
- Cdk2
- Cdk2
- Cdk3
- Cdk4
- Cdk5
- Cdk6
- Cdk7
- Cdk8
- Cdk9
- Cyclin A-activated cdc2
- Cyclin A-activated cdk2
- Cyclin D-cdk6 kinase
- Cyclin D-dependent kinase
- Cyclin E kinase
- Cyclin-A associated kinase
- Cyclin-dependent kinase 6
- Cyclin-dependent kinase-2
- Cyclin-dependent kinase-4
- Cyclin-dependent protein kinase activating kinase
- Cyk
- D-type cyclin kinase
- Nclk
- Neuronal cdc2-like kinase
- PCTAIRE-1
- STK25
GO terms
Biochemical function:
- protein serine kinase activity
- cyclin-dependent protein kinase activity
- metal ion binding
- histone kinase activity
- cyclin binding
- protein domain specific binding
- kinase activity
- ATP binding
- protein binding
- cyclin-dependent protein serine/threonine kinase activity
- protein serine/threonine kinase activity
- protein kinase activity
- magnesium ion binding
Biological process:
- regulation of anaphase-promoting complex-dependent catabolic process
- cellular senescence
- cellular response to nitric oxide
- meiotic cell cycle
- cell division
- centrosome duplication
- positive regulation of DNA-templated transcription
- positive regulation of DNA replication
- post-translational protein modification
- telomere maintenance in response to DNA damage
- positive regulation of DNA-templated DNA replication initiation
- mitotic G1 DNA damage checkpoint signaling
- positive regulation of heterochromatin formation
- peptidyl-serine phosphorylation
- regulation of gene expression
- regulation of G2/M transition of mitotic cell cycle
- positive regulation of cell population proliferation
- regulation of mitotic cell cycle
- Ras protein signal transduction
- signal transduction
- centriole replication
- potassium ion transport
- protein phosphorylation
- DNA-templated transcription
- chromatin remodeling
- DNA repair
- DNA replication
- negative regulation of transcription by RNA polymerase II
- G2/M transition of mitotic cell cycle
- G1/S transition of mitotic cell cycle
Cellular component:
- cyclin E2-CDK2 complex
- cyclin E1-CDK2 complex
- cyclin A2-CDK2 complex
- cyclin A1-CDK2 complex
- Cajal body
- cytoskeleton
- cytosol
- centrosome
- endosome
- cytoplasm
- transcription regulator complex
- nucleoplasm
- nuclear envelope
- nucleus
- male germ cell nucleus
- Y chromosome
- X chromosome
- condensed chromosome
- chromosome, telomeric region
- cyclin-dependent protein kinase holoenzyme complex
Sequence family
Protein family (Pfam)
InterPro annotationsStructure domains
CATH domains
1.10.510.10
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Transferase(Phosphotransferase); domain 1
Homology:
Transferase(Phosphotransferase) domain 1
Occurring in:
SCOP annotation