› 1pz0

X-ray diffraction
2.35Å resolution

Structure of NADPH-dependent family 11 aldo-keto reductase AKR11A(holo)

Released:
DOI: 10.2210/pdb1pz0/pdb
PDB entry 1pz0 coloured by chain, front view.
PDB entry 1pz0 coloured by chain, side view.
PDB entry 1pz0 coloured by chain, top view.
Source organism: Bacillus subtilis
Primary publication:
Structural and catalytic diversity in the two family 11 aldo-keto reductases.
Ehrensberger AH, Wilson DK
J Mol Biol 337 661-73 (2004)
PMID: 15019785

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-545811 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aldo-keto reductase IolS Chain: A
Molecule details ›
Chain: A
Length: 312 amino acids
Theoretical weight: 35.51 KDa
Source organism: Bacillus subtilis
Expression system: Escherichia coli
UniProt:
  • Canonical: P46336 (Residues: 1-310; Coverage: 100%)
Gene names: BSU39780, SS92ER, iolS, yxbF
Sequence domains: Aldo/keto reductase family
Structure domains: NADP-dependent oxidoreductase domain

Ligands and Environments

2 bound ligands:
Ligand NA 1 x NA
Ligand NAP 1 x NAP
1 modified residue:
Ligand MSE 3 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P212121
Unit cell:
a: 45.525Å b: 84.262Å c: 93.953Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.189 0.256
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Understanding nature's catalytic toolkit.
Gutteridge et al. (2005)
16 other articles

3 mentions without citation

Identification of a novel NADH-specific aldo-keto reductase using sequence and structural homologies.
Di Luccio et al. (2006)
2 more