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Crystal structures of two UBC (E2) enzymes of the ubiquitin-conjugating system in Caenorhabditis elegans

Source organism: Caenorhabditis elegans
Biochemical function: ubiquitin conjugating enzyme activity
Biological process: proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular component: not assigned

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EC 2.3.2.23: E2 ubiquitin-conjugating enzyme

Reaction catalysed:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
Systematic name:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
Alternative Name(s):
  • UBC
  • Ubiquitin-carrier-protein E2
  • Ubiquitin-conjugating enzyme E2

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00179
Domain description: Ubiquitin-conjugating enzyme
Occurring in:
  1. Probable ubiquitin-conjugating enzyme E2 7
The deposited structure of PDB entry 1pzv contains 1 copy of Pfam domain PF00179 (Ubiquitin-conjugating enzyme) in Probable ubiquitin-conjugating enzyme E2 7. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000608
Domain description: Ubiquitin-conjugating enzyme E2, catalytic core domain
Occurring in:
  1. Probable ubiquitin-conjugating enzyme E2 7
IPR016135
Domain description: Ubiquitin-conjugating enzyme/RWD-like
Occurring in:
  1. Probable ubiquitin-conjugating enzyme E2 7
IPR023313
Domain description: Ubiquitin-conjugating enzyme, active site
Occurring in:
  1. Probable ubiquitin-conjugating enzyme E2 7

Structure domain

CATH CATH domain
3.10.110.10
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin Conjugating Enzyme
Homology: Ubiquitin Conjugating Enzyme
Occurring in:
  1. Probable ubiquitin-conjugating enzyme E2 7
The deposited structure of PDB entry 1pzv contains 1 copy of CATH domain 3.10.110.10 (Ubiquitin Conjugating Enzyme) in Probable ubiquitin-conjugating enzyme E2 7. Showing 1 copy in chain A.
SCOP SCOP annotation
54496
Class: Alpha and beta proteins (a+b)
Fold: UBC-like
Superfamily: UBC-like
Occurring in:
  1. Probable ubiquitin-conjugating enzyme E2 7
The deposited structure of PDB entry 1pzv contains 1 copy of SCOP domain 54496 (UBC-related) in Probable ubiquitin-conjugating enzyme E2 7. Showing 1 copy in chain A.

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