› 1q2h

X-ray diffraction
1.7Å resolution

Phenylalanine Zipper Mediates APS Dimerization

Released:
DOI: 10.2210/pdb1q2h/pdb
PDB entry 1q2h coloured by chain, front view.
PDB entry 1q2h coloured by chain, side view.
PDB entry 1q2h coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A phenylalanine zipper mediates APS dimerization.
Dhe-Paganon S, Werner ED, Nishi M, Hansen L, Chi YI, Shoelson SE
Nat Struct Mol Biol 11 968-74 (2004)
PMID: 15378031

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126978 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SH2B adapter protein 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 69 amino acids
Theoretical weight: 7.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14492 (Residues: 20-85; Coverage: 10%)
Gene names: APS, SH2B2
Sequence domains: Phenylalanine zipper
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P21212
Unit cell:
a: 69.74Å b: 57.48Å c: 51.72Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.25 0.25 0.27
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

10 review citations

The molecular details of cytokine signaling via the JAK/STAT pathway.
Morris et al. (2018)
9 more

3 mentions without citation

The Role of LNK (SH2B3) in the Regulation of JAK-STAT Signalling in Haematopoiesis.
Morris et al. (2021)
2 more