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Crystal structure of rat choline acetyltransferase

Source organism: Rattus norvegicus
Biochemical function: choline binding
Biological process: response to ethanol
Cellular component: synapse

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EC 2.3.1.6: Choline O-acetyltransferase

Reaction catalysed:
Acetyl-CoA + choline = CoA + O-acetylcholine
Systematic name:
Acetyl-CoA:choline O-acetyltransferase
Alternative Name(s):
  • CHOACTase
  • Choline acetylase
  • Choline acetyltransferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00755
Domain description: Choline/Carnitine o-acyltransferase
Occurring in:
  1. Choline O-acetyltransferase
The deposited structure of PDB entry 1q6x contains 2 copies of Pfam domain PF00755 (Choline/Carnitine o-acyltransferase) in Choline O-acetyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000542
Domain description: Acyltransferase ChoActase/COT/CPT
Occurring in:
  1. Choline O-acetyltransferase
IPR042231
Domain description: Choline/Carnitine o-acyltransferase, domain 2
Occurring in:
  1. Choline O-acetyltransferase
IPR039551
Domain description: Choline/carnitine acyltransferase domain
Occurring in:
  1. Choline O-acetyltransferase
IPR023213
Domain description: Chloramphenicol acetyltransferase-like domain superfamily
Occurring in:
  1. Choline O-acetyltransferase

Structure domains

CATH CATH domains
3.30.559.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Chloramphenicol Acetyltransferase
Homology: Chloramphenicol acetyltransferase-like domain
Occurring in:
  1. Choline O-acetyltransferase
The deposited structure of PDB entry 1q6x contains 2 copies of CATH domain 3.30.559.10 (Chloramphenicol Acetyltransferase) in Choline O-acetyltransferase. Showing 1 copy in chain A.
3.30.559.70
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Chloramphenicol Acetyltransferase
Homology: Choline/Carnitine o-acyltransferase, domain 2
Occurring in:
  1. Choline O-acetyltransferase
The deposited structure of PDB entry 1q6x contains 2 copies of CATH domain 3.30.559.70 (Chloramphenicol Acetyltransferase) in Choline O-acetyltransferase. Showing 1 copy in chain A.
SCOP SCOP annotation
82424
Class: Alpha and beta proteins (a/b)
Fold: CoA-dependent acyltransferases
Superfamily: CoA-dependent acyltransferases
Occurring in:
  1. Choline O-acetyltransferase
The deposited structure of PDB entry 1q6x contains 4 copies of SCOP domain 82424 (Choline/Carnitine O-acyltransferase) in Choline O-acetyltransferase. Showing 2 copies in chain A.

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