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Crystal structure of the human myeloid cell activating receptor TREM-1.

Radaev S, Kattah M, Rostro B, Colonna M, Sun PD
Structure 11 1527-35 (2003)
Cited: 48 times
EuropePMC logo PMID: 14656437

Abstract

Triggering receptors expressed on myeloid cells (TREM) are a family of recently discovered receptors that play important roles in innate immune responses, such as to activate inflammatory responses and to contribute to septic shock in response to microbial-mediated infections. To date, two TREM receptors in human and several homologs in mice have been identified. We report the 2.6 A resolution crystal structure of the extracellular domain of human TREM-1. The overall fold of the receptor resembles that of a V-type immunoglobulin domain with differences primarily located in the N-terminal strand. TREM-1 forms a "head-to-tail" dimer with 4100 A(2) interface area that is partially mediated by a domain swapping between the first strands. This mode of dimer formation is different from the "head-to-head" dimerization that existed in V(H)V(L) domains of antibodies or V domains of T cell receptors. As a result, the dimeric TREM-1 most likely contains two distinct ligand binding sites.

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  1. Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor. Radaev S, Zou Z, Tolar P, Nguyen K, Nguyen A, Krueger PD, Stutzman N, Pierce S, Sun PD. Structure 18 934-943 (2010)
  2. Analysis of domain-swapped oligomers reveals local sequence preferences and structural imprints at the linker regions and swapped interfaces. Shingate P, Sowdhamini R. PLoS One 7 e39305 (2012)
  3. Linking in domain-swapped protein dimers. Baiesi M, Orlandini E, Trovato A, Seno F. Sci Rep 6 33872 (2016)
  4. The enigma of the near-symmetry of proteins: Domain swapping. Bonjack-Shterengartz M, Avnir D. PLoS One 12 e0180030 (2017)
  5. A structural model of the immune checkpoint CD160-HVEM complex derived from HDX-mass spectrometry and molecular modeling. Kuncewicz K, Spodzieja M, Sieradzan A, Karczyńska A, Dąbrowska K, Dadlez M, Speiser DE, Derre L, Rodziewicz-Motowidło S. Oncotarget 10 536-550 (2019)
  6. The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins. Chakraborty S, Rendón-Ramírez A, Ásgeirsson B, Dutta M, Ghosh AS, Oda M, Venkatramani R, Rao BJ, Dandekar AM, Goñi FM. F1000Res 2 286 (2013)


Reviews citing this publication (17)

  1. The TREM receptor family and signal integration. Klesney-Tait J, Turnbull IR, Colonna M. Nat Immunol 7 1266-1273 (2006)
  2. From expression to signaling: roles of TREM-1 and TREM-2 in innate immunity and bacterial infection. Sharif O, Knapp S. Immunobiology 213 701-713 (2008)
  3. The TREM-1/DAP12 pathway. Tessarz AS, Cerwenka A. Immunol Lett 116 111-116 (2008)
  4. Clinical review: role of triggering receptor expressed on myeloid cells-1 during sepsis. Gibot S. Crit Care 9 485-489 (2005)
  5. Triggering receptor expressed on myeloid cells-1 (TREM-1): a new player in antiviral immunity? Roe K, Gibot S, Verma S. Front Microbiol 5 627 (2014)
  6. Triggering receptor expressed on myeloid cells receptor family modulators: a patent review. Pelham CJ, Pandya AN, Agrawal DK. Expert Opin Ther Pat 24 1383-1395 (2014)
  7. The structural basis of ligand recognition by natural killer cell receptors. Joyce MG, Sun PD. J Biomed Biotechnol 2011 203628 (2011)
  8. Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis of infectious diseases. Cao C, Gu J, Zhang J. Front Med 11 169-177 (2017)
  9. Triggering receptor expressed on myeloid cells type 1 as a potential therapeutic target in sepsis. Palazzo SJ, Simpson T, Schnapp LM. Dimens Crit Care Nurs 31 1-6 (2012)
  10. Triggering receptor expressed on myeloid cells and 5'adenosine monophosphate-activated protein kinase in the inflammatory response: a potential therapeutic target. Thankam FG, Dilisio MF, Dougherty KA, Dietz NE, Agrawal DK. Expert Rev Clin Immunol 12 1239-1249 (2016)
  11. Function of TREM1 and TREM2 in Liver-Related Diseases. Sun H, Feng J, Tang L. Cells 9 E2626 (2020)
  12. Triggering Receptor Expressed on Myeloid Cells-1 Signaling: Protective and Pathogenic Roles on Streptococcal Toxic-Shock-Like Syndrome Caused by Streptococcus suis. Han L, Fu L, Peng Y, Zhang A. Front Immunol 9 577 (2018)
  13. Novel ligands and modulators of triggering receptor expressed on myeloid cells receptor family: 2015-2020 updates. Singh H, Rai V, Nooti SK, Agrawal DK. Expert Opin Ther Pat 31 549-561 (2021)
  14. Targeting Mononuclear Phagocyte Receptors in Cancer Immunotherapy: New Perspectives of the Triggering Receptor Expressed on Myeloid Cells (TREM-1). Raggi F, Bosco MC. Cancers (Basel) 12 E1337 (2020)
  15. The biology of TREM receptors. Colonna M. Nat Rev Immunol (2023)
  16. The role of triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases. Zhang C, Kan X, Zhang B, Ni H, Shao J. Mol Brain 15 84 (2022)
  17. Triggering receptor expressed on myeloid cells-1 in sepsis, and current insights into clinical studies. Theobald V, Schmitt FCF, Middel CS, Gaissmaier L, Brenner T, Weigand MA. Crit Care 28 17 (2024)

Articles citing this publication (25)

  1. A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. Gibot S, Kolopp-Sarda MN, Béné MC, Bollaert PE, Lozniewski A, Mory F, Levy B, Faure GC. J Exp Med 200 1419-1426 (2004)
  2. Modulation of the triggering receptor expressed on the myeloid cell type 1 pathway in murine septic shock. Gibot S, Buonsanti C, Massin F, Romano M, Kolopp-Sarda MN, Benigni F, Faure GC, Béné MC, Panina-Bordignon P, Passini N, Lévy B. Infect Immun 74 2823-2830 (2006)
  3. TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance. Weber B, Schuster S, Zysset D, Rihs S, Dickgreber N, Schürch C, Riether C, Siegrist M, Schneider C, Pawelski H, Gurzeler U, Ziltener P, Genitsch V, Tacchini-Cottier F, Ochsenbein A, Hofstetter W, Kopf M, Kaufmann T, Oxenius A, Reith W, Saurer L, Mueller C. PLoS Pathog 10 e1003900 (2014)
  4. Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke. Xu P, Zhang X, Liu Q, Xie Y, Shi X, Chen J, Li Y, Guo H, Sun R, Hong Y, Liu X, Xu G. Cell Death Dis 10 555 (2019)
  5. The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment. Gattis JL, Washington AV, Chisholm MM, Quigley L, Szyk A, McVicar DW, Lubkowski J. J Biol Chem 281 13396-13403 (2006)
  6. Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A. Kelker MS, Foss TR, Peti W, Teyton L, Kelly JW, Wüthrich K, Wilson IA. J Mol Biol 342 1237-1248 (2004)
  7. Novel immunoglobulin-like transcripts in teleost fish encode polymorphic receptors with cytoplasmic ITAM or ITIM and a new structural Ig domain similar to the natural cytotoxicity receptor NKp44. Stet RJ, Hermsen T, Westphal AH, Jukes J, Engelsma M, Lidy Verburg-van Kemenade BM, Dortmans J, Aveiro J, Savelkoul HF. Immunogenetics 57 77-89 (2005)
  8. Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.76 A. Kelker MS, Debler EW, Wilson IA. J Mol Biol 344 1175-1181 (2004)
  9. The crystal structure of the extracellular domain of the inhibitor receptor expressed on myeloid cells IREM-1. Márquez JA, Galfré E, Dupeux F, Flot D, Moran O, Dimasi N. J Mol Biol 367 310-318 (2007)
  10. Identification of a Novel Splice Variant Isoform of TREM-1 in Human Neutrophil Granules. Baruah S, Keck K, Vrenios M, Pope MR, Pearl M, Doerschug K, Klesney-Tait J. J Immunol 195 5725-5731 (2015)
  11. Distinct signaling cascades of TREM-1, TLR and NLR in neutrophils and monocytic cells. Prüfer S, Weber M, Sasca D, Teschner D, Wölfel C, Stein P, Stassen M, Schild H, Radsak MP. J Innate Immun 6 339-352 (2014)
  12. Triggering receptor in myeloid cells (TREM-1) specific expression in peripheral blood mononuclear cells of sepsis patients with acute cholangitis. Liao R, Liu Z, Wei S, Xu F, Chen Z, Gong J. Inflammation 32 182-190 (2009)
  13. TREM-1 multimerization is essential for its activation on monocytes and neutrophils. Carrasco K, Boufenzer A, Jolly L, Le Cordier H, Wang G, Heck AJ, Cerwenka A, Vinolo E, Nazabal A, Kriznik A, Launay P, Gibot S, Derive M. Cell Mol Immunol 16 460-472 (2019)
  14. Activation of the TREM-1 pathway in human monocytes by periodontal pathogens and oral commensal bacteria. Varanat M, Haase EM, Kay JG, Scannapieco FA. Mol Oral Microbiol 32 275-287 (2017)
  15. Rainbow trout (Oncorhynchus mykiss) possess multiple novel immunoglobulin-like transcripts containing either an ITAM or ITIMs. Østergaard AE, Martin SA, Wang T, Stet RJ, Secombes CJ. Dev Comp Immunol 33 525-532 (2009)
  16. The SCHOOL of nature: I. Transmembrane signaling. Sigalov AB. Self Nonself 1 4-39 (2010)
  17. Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseases. Kober DL, Wanhainen KM, Johnson BM, Randolph DT, Holtzman MJ, Brett TJ. Protein Expr Purif 96 32-38 (2014)
  18. Relationships between genetic polymorphisms of triggering receptor expressed on myeloid cells-1 and septic shock in a Chinese Han population. Peng LS, Li J, Zhou GS, Deng LH, Yao HG. World J Emerg Med 6 123-130 (2015)
  19. Genomic organisation analysis of novel immunoglobulin-like transcripts in Atlantic salmon (Salmo salar) reveals a tightly clustered and multigene family. Ostergaard AE, Lubieniecki KP, Martin SA, Stet RJ, Davidson WS, Secombes CJ. BMC Genomics 11 697 (2010)
  20. The SCHOOL of nature: III. From mechanistic understanding to novel therapies. Sigalov AB. Self Nonself 1 192-224 (2010)
  21. Hsp70 Interacts with the TREM-1 Receptor Expressed on Monocytes and Thereby Stimulates Generation of Cytotoxic Lymphocytes Active against MHC-Negative Tumor Cells. Sharapova TN, Romanova EA, Ivanova OK, Yashin DV, Sashchenko LP. Int J Mol Sci 22 6889 (2021)
  22. N-Terminal Peptide of PGLYRP1/Tag7 Is a Novel Ligand for TREM-1 Receptor. Sharapova TN, Ivanova OK, Romanova EA, Sashchenko LP, Yashin DV. Int J Mol Sci 23 5752 (2022)
  23. Protein PGLYRP1/Tag7 Peptides Decrease the Proinflammatory Response in Human Blood Cells and Mouse Model of Diffuse Alveolar Damage of Lung through Blockage of the TREM-1 and TNFR1 Receptors. Sharapova TN, Romanova EA, Chernov AS, Minakov AN, Kazakov VA, Kudriaeva AA, Belogurov AA, Ivanova OK, Gabibov AG, Telegin GB, Yashin DV, Sashchenko LP. Int J Mol Sci 22 11213 (2021)
  24. The CDR3 region as the major driver of TREM-1 interaction with its ligands, an in silico characterization. de Oliveira Matos A, Dos Santos Dantas PH, Colmenares MTC, Sartori GR, Silva-Sales M, Da Silva JHM, Neves BJ, Andrade CH, Sales-Campos H. Comput Struct Biotechnol J 21 2579-2590 (2023)
  25. CRDSAT Generated by pCARGHO: A New Efficient Lectin-Based Affinity Tag Method for Safe, Simple, and Low-Cost Protein Purification. Kriznik A, Yéléhé-Okouma M, Lec JC, Groshenry G, Le Cordier H, Charron C, Quinternet M, Mazon H, Talfournier F, Boschi-Muller S, Jouzeau JY, Reboul P. Biotechnol J 14 e1800214 (2019)


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