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INNERMOST LIPOYL DOMAIN OF THE PYRUVATE DEHYDROGENASE FROM ESCHERICHIA COLI

Source organism: Escherichia coli BL21(DE3)
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 2.3.1.12: Dihydrolipoyllysine-residue acetyltransferase

Reaction catalysed:
Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine
Systematic name:
Acetyl-CoA:enzyme-N(6)-(dihydrolipoyl)lysine S-acetyltransferase
Alternative Name(s):
  • Acetyl-CoA: enzyme-6-N-(dihydrolipoyl)lysine S-acetyltransferase
  • Acetyl-CoA:dihydrolipoamide S-acetyltransferase
  • Dihydrolipoamide S-acetyltransferase
  • Dihydrolipoate acetyltransferase
  • Dihydrolipoic transacetylase
  • Dihydrolipoyl acetyltransferase
  • Enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase
  • Lipoate acetyltransferase
  • Lipoate transacetylase
  • Lipoic acetyltransferase
  • Lipoic acid acetyltransferase
  • Lipoic transacetylase
  • Lipoylacetyltransferase
  • Thioltransacetylase A
  • Transacetylase X

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00364
Domain description: Biotin-requiring enzyme
Occurring in:
  1. Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
The deposited structure of PDB entry 1qjo contains 1 copy of Pfam domain PF00364 (Biotin-requiring enzyme) in Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000089
Domain description: Biotin/lipoyl attachment
Occurring in:
  1. Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
IPR003016
Domain description: 2-oxo acid dehydrogenase, lipoyl-binding site
Occurring in:
  1. Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
IPR011053
Domain description: Single hybrid motif
Occurring in:
  1. Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

Structure domain

CATH CATH domain
2.40.50.100
Class: Mainly Beta
Architecture: Beta Barrel
Topology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Occurring in:
  1. Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
The deposited structure of PDB entry 1qjo contains 1 copy of CATH domain 2.40.50.100 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex. Showing 1 copy in chain A.
SCOP SCOP annotation
51231
Class: All beta proteins
Fold: Barrel-sandwich hybrid
Superfamily: Single hybrid motif
Occurring in:
  1. Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
The deposited structure of PDB entry 1qjo contains 1 copy of SCOP domain 51231 (Biotinyl/lipoyl-carrier proteins and domains) in Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex. Showing 1 copy in chain A.

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