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CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH INDOLE GLYCEROL PHOSPHATE

Source organism: Salmonella enterica subsp. enterica serovar Typhimurium
Biochemical function: lyase activity
Biological process: tryptophan metabolic process
Cellular component: cytoplasm

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EC 4.2.1.20: Tryptophan synthase

Reaction catalysed:
(1a) 1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate
Systematic name:
L-serine hydro-lyase (adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming)
Alternative Name(s):
  • Indoleglycerol phosphate aldolase
  • L-serine hydro-lyase (adding indoleglycerol-phosphate)
  • L-tryptophan synthetase
  • Tryptophan desmolase
  • Tryptophan synthetase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00291
Domain description: Pyridoxal-phosphate dependent enzyme
Occurring in:
  1. Tryptophan synthase beta chain
The deposited structure of PDB entry 1qoq contains 1 copy of Pfam domain PF00291 (Pyridoxal-phosphate dependent enzyme) in Tryptophan synthase beta chain. Showing 1 copy in chain B.

PF00290
Domain description: Tryptophan synthase alpha chain
Occurring in:
  1. Tryptophan synthase alpha chain
The deposited structure of PDB entry 1qoq contains 1 copy of Pfam domain PF00290 (Tryptophan synthase alpha chain) in Tryptophan synthase alpha chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002028
Domain description: Tryptophan synthase, alpha chain
Occurring in:
  1. Tryptophan synthase alpha chain
IPR036052
Domain description: Tryptophan synthase beta chain-like, PALP domain superfamily
Occurring in:
  1. Tryptophan synthase beta chain
IPR023026
Domain description: Tryptophan synthase beta chain/beta chain-like
Occurring in:
  1. Tryptophan synthase beta chain
IPR006654
Domain description: Tryptophan synthase, beta chain
Occurring in:
  1. Tryptophan synthase beta chain
IPR006653
Domain description: Tryptophan synthase, beta chain, conserved site
Occurring in:
  1. Tryptophan synthase beta chain
IPR001926
Domain description: Tryptophan synthase beta chain-like, PALP domain
Occurring in:
  1. Tryptophan synthase beta chain
IPR018204
Domain description: Tryptophan synthase, alpha chain, active site
Occurring in:
  1. Tryptophan synthase alpha chain
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Tryptophan synthase alpha chain
IPR011060
Domain description: Ribulose-phosphate binding barrel
Occurring in:
  1. Tryptophan synthase alpha chain

Structure domains

CATH CATH domains
3.40.50.1100
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Tryptophan synthase beta chain
The deposited structure of PDB entry 1qoq contains 2 copies of CATH domain 3.40.50.1100 (Rossmann fold) in Tryptophan synthase beta chain. Showing 2 copies in chain B.
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. Tryptophan synthase alpha chain
The deposited structure of PDB entry 1qoq contains 1 copy of CATH domain 3.20.20.70 (TIM Barrel) in Tryptophan synthase alpha chain. Showing 1 copy in chain A.
SCOP SCOP annotations
53687
Class: Alpha and beta proteins (a/b)
Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes
Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes
Occurring in:
  1. Tryptophan synthase beta chain
The deposited structure of PDB entry 1qoq contains 1 copy of SCOP domain 53687 (Tryptophan synthase beta subunit-like PLP-dependent enzymes) in Tryptophan synthase beta chain. Showing 1 copy in chain B.
51381
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: Ribulose-phoshate binding barrel
Occurring in:
  1. Tryptophan synthase alpha chain
The deposited structure of PDB entry 1qoq contains 1 copy of SCOP domain 51381 (Tryptophan biosynthesis enzymes) in Tryptophan synthase alpha chain. Showing 1 copy in chain A.

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