› 1qvx

Solution NMR

SOLUTION STRUCTURE OF THE FAT DOMAIN OF FOCAL ADHESION KINASE

Released:
DOI: 10.2210/pdb1qvx/pdb
PDB entry 1qvx coloured by chain, ensemble of 25 models, front view.
PDB entry 1qvx coloured by chain, ensemble of 25 models, side view.
PDB entry 1qvx coloured by chain, ensemble of 25 models, top view.
Source organism: Gallus gallus
Primary publication:
NMR solution structure of the focal adhesion targeting domain of focal adhesion kinase in complex with a paxillin LD peptide: evidence for a two-site binding model.
Gao G, Prutzman KC, King ML, Scheswohl DM, DeRose EF, London RE, Schaller MD, Campbell SL
J Biol Chem 279 8441-51 (2004)
PMID: 14662767

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169484 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Focal adhesion kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 134 amino acids
Theoretical weight: 15 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q00944 (Residues: 920-1053; Coverage: 13%)
Gene names: FAK, FAK1, PTK2
Sequence domains: Focal adhesion targeting region
Structure domains: Nucleotidyltransferases domain 2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 69%
Refinement method: The program CNS version 1.1 with ARIA version 1.2 module was used to calculate the structures of the avian FAT domain.
Expression system: Escherichia coli

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Citations

13 review citations

Focal adhesion kinase: in command and control of cell motility.
Mitra et al. (2005)
12 more