Function and Biology

crystal structure of a human mitochondrial ferritin

Source organism: Homo sapiens
Biochemical function: ferric iron binding
Biological process: intracellular iron ion homeostasis
Cellular component: not assigned

EC 1.16.3.1: Ferroxidase

Reaction catalysed:
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Systematic name:
Fe(II):oxygen oxidoreductase
Alternative Name(s):
  • Caeruloplasmin
  • Ceruloplasmin
  • Ferro:O(2) oxidoreductase
  • Ferroxidase I
  • HEPH
  • Hephaestin
  • Iron II:oxygen oxidoreductase
  • Iron oxidase
  • Iron(II):oxygen oxidoreductase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00210
Domain description: Ferritin-like domain
Occurring in:
  1. Ferritin, mitochondrial
The deposited structure of PDB entry 1r03 contains 1 copy of Pfam domain PF00210 (Ferritin-like domain) in Ferritin, mitochondrial. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR014034
Domain description: Ferritin, conserved site
Occurring in:
  1. Ferritin, mitochondrial
IPR008331
Domain description: Ferritin/DPS protein domain
Occurring in:
  1. Ferritin, mitochondrial
IPR009040
Domain description: Ferritin-like diiron domain
Occurring in:
  1. Ferritin, mitochondrial
IPR001519
Domain description: Ferritin
Occurring in:
  1. Ferritin, mitochondrial
IPR009078
Domain description: Ferritin-like superfamily
Occurring in:
  1. Ferritin, mitochondrial
IPR012347
Domain description: Ferritin-like
Occurring in:
  1. Ferritin, mitochondrial

Structure domain

CATH CATH domain
1.20.1260.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Ferritin
Homology: Ferritin
Occurring in:
  1. Ferritin, mitochondrial
The deposited structure of PDB entry 1r03 contains 1 copy of CATH domain 1.20.1260.10 (Ferritin) in Ferritin, mitochondrial. Showing 1 copy in chain A.
SCOP SCOP annotation
47241
Class: All alpha proteins
Fold: Ferritin-like
Superfamily: Ferritin-like
Occurring in:
  1. Ferritin, mitochondrial
The deposited structure of PDB entry 1r03 contains 1 copy of SCOP domain 47241 (Ferritin) in Ferritin, mitochondrial. Showing 1 copy in chain A.