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Transketolase from Leishmania mexicana

X-ray diffraction
2.22Å resolution
PDB entry 1r9j coloured by chain, front view.
PDB entry 1r9j coloured by chain, side view.
PDB entry 1r9j coloured by chain, top view.
Source organism: Leishmania mexicana mexicana
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Transketolase
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Multimeric state: homo dimer
Accessible surface area: 40547.67 Å2
Buried surface area: 10280.73 Å2
Dissociation area: 4,399.39 Å2
Dissociation energy (ΔGdiss): 46.3 kcal/mol
Dissociation entropy (TΔSdiss): 16.26 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-185322
Homo dimeric assembly 1 of PDB entry 1r9j coloured by chemically distinct molecules, front view.
Homo dimeric assembly 1 of PDB entry 1r9j coloured by chemically distinct molecules, side view.
Homo dimeric assembly 1 of PDB entry 1r9j coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 98%
No. subunits : 2
Symmetry : C2
More details
3DComplex & QSbio predictionx
No. subunits : 2
Symmetry : C2
Evidence : Interface geometry is similar to that of 4c7v_1 (46% id)

Macromolecules

Transketolase
Chains: A, B
Length: 673 amino acids
Theoretical weight: 72.2 KDa
Source organism: Leishmania mexicana mexicana
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8MPM3 (Residues: 1-671; Coverage: 100%)
Gene name: TKT
Pfam:
InterPro:
CATH:
SCOP:
Transketolase in PDB entry 1r9j, assembly 1, front view.
Transketolase in PDB entry 1r9j, assembly 1, side view.
Transketolase in PDB entry 1r9j, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q8MPM3  
167350100150200250300350400450500550600650
 
200400600RHMASIEKVANCIRCLAADIVQGGKSGHPGTPMGMAPMSAVLWTEVMKYNSQDPDWVDRDRFVMSNGHGCALQYALLHMAGYNLTMDDLKGFRQDGSRTPGHPERFVTPGVEVTTGPLGQGIANAVGLAIAEAHLAATFNRPGYNIVDHYTYVYCGDGCLMEGVCQEALSLAGHLALEKLIVIYDSNYISIDGSTSLSFTEQCHQKYVAMGFHVIEVKNGDTDYEGLRKALAEAKATKGKPKMIVQTTTIGFGSSKQGTEKVHGAPLGEEDIANIKAKFGRDPQKKYDVDDDVRAVFRMHIDKCSAEQKAWEELLAKYTAAFPAEGAAFVAQMRGELPSGWEAKLPTNSSAIATRKASENCLAVLFPAIPALMGGSADLTPSNLTRPASANLVDFSSSSKEGRYIRFGVREHAMCAILNGLDAHDGIIPFGGTFLNFIGYALGAVRLAAISHHRVIYVATHDSIGVGEDGPTHQPVELVAALRAMPNLQVIRPSDQTETSGAWAVALSSIHTPTVLCLSRQNTEPQSGSSIEGVRHGAYSVVDVPDLQLVIVASGSEVSLAVDAAKALSGELRVRVVSMPCQELFDAQPDTYRQAVLPAGVPVVSVEAYVSFGWEKYSHAHVGMSGFGASAPAGVLYKKFGITVEEVVRTGRELAKRFPDGTAPLKNSSFSKM
UniProt
Q8MPM3
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

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