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Structure of a ribonuclease B+d(pA)4 complex.

Ko TP, Williams R, McPherson A
Acta Crystallogr D Biol Crystallogr 52 160-4 (1996)
Cited: 6 times
EuropePMC logo PMID: 15299737

Abstract

The structure of a tetragonal crystal of bovine pancreatic RNase B complexed with d(pA)(4) was determined by molecular replacement and difference Fourier methods. This crystal belongs to space group P4(1)2(1)2 and has unit-cell dimensions a = b = 44.5, c = 156.5 A. The model consists of the enzyme and a tetranucleotide with fractional occupancies, suggesting multiple modes of oligonucleotide binding. It does not include any polysaccharide residues or solvent molecules. After refinement at 2.7 A, the R value was 0.163 with acceptable stereochemistry. The model illustrates a set of well defined interactions for substrate binding, particularly between the central dinucleotide and the enzyme.

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  2. Stretching to understand proteins - a survey of the protein data bank. SuĊ‚kowska JI, Cieplak M. Biophys J 94 6-13 (2008)
  3. NMR of hydrogen bonding in cold-shock protein A and an analysis of the influence of crystallographic resolution on comparisons of hydrogen bond lengths. Alexandrescu AT, Snyder DR, Abildgaard F. Protein Sci. 10 1856-1868 (2001)


Articles citing this publication (3)

  1. Recognition of nucleic acid bases and base-pairs by hydrogen bonding to amino acid side-chains. Cheng AC, Chen WW, Fuhrmann CN, Frankel AD. J. Mol. Biol. 327 781-796 (2003)
  2. Structural basis for the selection of glycosylated substrates by SCF(Fbs1) ubiquitin ligase. Mizushima T, Yoshida Y, Kumanomidou T, Hasegawa Y, Suzuki A, Yamane T, Tanaka K. Proc. Natl. Acad. Sci. U.S.A. 104 5777-5781 (2007)
  3. Multiple ligand-binding modes in bacterial R67 dihydrofolate reductase. Alonso H, Gillies MB, Cummins PL, Bliznyuk AA, Gready JE. J Comput Aided Mol Des 19 165-187 (2005)


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