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The crystal structure of the D-aminoacylase D366A mutant in complex with 100mM ZnCl2

Source organism: Alcaligenes faecalis
Biochemical function: N-acyl-D-amino-acid deacylase activity
Biological process: not assigned
Cellular component: not assigned

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EC 3.5.1.81: N-acyl-D-amino-acid deacylase

Reaction catalysed:
N-acyl-D-amino acid + H(2)O = a carboxylate + D-amino acid
Systematic name:
N-acyl-D-amino acid amidohydrolase
Alternative Name(s):
  • D-aminoacylase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF07969
Domain description: Amidohydrolase family
Occurring in:
  1. Amidohydrolase 3 domain-containing protein
The deposited structure of PDB entry 1rjr contains 2 copies of Pfam domain PF07969 (Amidohydrolase family) in Amidohydrolase 3 domain-containing protein. Showing 2 copies in chain A.

InterPro InterPro annotations
IPR013108
Domain description: Amidohydrolase 3
Occurring in:
  1. Amidohydrolase 3 domain-containing protein
IPR011059
Domain description: Metal-dependent hydrolase, composite domain superfamily
Occurring in:
  1. Amidohydrolase 3 domain-containing protein
IPR023100
Domain description: D-aminoacylase, insert domain superfamily
Occurring in:
  1. Amidohydrolase 3 domain-containing protein
IPR032466
Domain description: Metal-dependent hydrolase
Occurring in:
  1. Amidohydrolase 3 domain-containing protein

Structure domains

CATH CATH domains
2.30.40.10
Class: Mainly Beta
Architecture: Roll
Topology: Urease, subunit C; domain 1
Homology: Urease, subunit C, domain 1
Occurring in:
  1. Amidohydrolase 3 domain-containing protein
The deposited structure of PDB entry 1rjr contains 1 copy of CATH domain 2.30.40.10 (Urease, subunit C; domain 1) in Amidohydrolase 3 domain-containing protein. Showing 1 copy in chain A.
3.20.20.140
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Metal-dependent hydrolases
Occurring in:
  1. Amidohydrolase 3 domain-containing protein
The deposited structure of PDB entry 1rjr contains 1 copy of CATH domain 3.20.20.140 (TIM Barrel) in Amidohydrolase 3 domain-containing protein. Showing 1 copy in chain A.
3.30.1490.130
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Dna Ligase; domain 1
Homology: D-aminoacylase. Domain 3
Occurring in:
  1. Amidohydrolase 3 domain-containing protein
The deposited structure of PDB entry 1rjr contains 1 copy of CATH domain 3.30.1490.130 (Dna Ligase; domain 1) in Amidohydrolase 3 domain-containing protein. Showing 1 copy in chain A.
SCOP SCOP annotations
82230
Class: All beta proteins
Fold: Composite domain of metallo-dependent hydrolases
Superfamily: Composite domain of metallo-dependent hydrolases
Occurring in:
  1. Amidohydrolase 3 domain-containing protein
The deposited structure of PDB entry 1rjr contains 2 copies of SCOP domain 82230 (D-aminoacylase) in Amidohydrolase 3 domain-containing protein. Showing 2 copies in chain A.
82264
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: Metallo-dependent hydrolases
Occurring in:
  1. Amidohydrolase 3 domain-containing protein
The deposited structure of PDB entry 1rjr contains 1 copy of SCOP domain 82264 (D-aminoacylase, catalytic domain) in Amidohydrolase 3 domain-containing protein. Showing 1 copy in chain A.

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