› 1rq2

X-ray diffraction
1.86Å resolution

MYCOBACTERIUM TUBERCULOSIS FTSZ IN COMPLEX WITH CITRATE

Released:
DOI: 10.2210/pdb1rq2/pdb
PDB entry 1rq2 coloured by chain, front view.
PDB entry 1rq2 coloured by chain, side view.
PDB entry 1rq2 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches.
Leung AK, Lucile White E, Ross LJ, Reynolds RC, DeVito JA, Borhani DW
J Mol Biol 342 953-70 (2004)
PMID: 15342249

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161841 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cell division protein FtsZ Chains: A, B
Molecule details ›
Chains: A, B
Length: 382 amino acids
Theoretical weight: 39.07 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WN95 (Residues: 1-379; Coverage: 100%)
Gene names: MTCY270.18, Rv2150c, ftsZ
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CIT 1 x CIT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P65
Unit cell:
a: 88.116Å b: 88.116Å c: 176.807Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.187 0.222
Expression system: Escherichia coli

Quick links

Citations

17 review citations

Bacterial growth and cell division: a mycobacterial perspective.
Hett et al. (2008)
16 more

8 mentions without citation

E93R substitution of Escherichia coli FtsZ induces bundling of protofilaments, reduces GTPase activity, and impairs bacterial cytokinesis.
Jaiswal et al. (2010)
7 more