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Crystal structure and mechanism of a bacterial fluorinating enzyme

Source organism: Streptomyces cattleya
Biochemical function: adenosyl-fluoride synthase activity
Biological process: not assigned
Cellular component: not assigned

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EC 2.5.1.63: Adenosyl-fluoride synthase

Reaction catalysed:
S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine
Systematic name:
S-adenosyl-L-methionine:fluoride adenosyltransferase
Alternative Name(s):
  • Fluorinase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF01887
Domain description: SAM hydroxide adenosyltransferase N-terminal domain
Occurring in:
  1. Fluorinase
The deposited structure of PDB entry 1rqp contains 6 copies of Pfam domain PF01887 (SAM hydroxide adenosyltransferase N-terminal domain) in Fluorinase. Showing 2 copies in chain A.

PF20257
Domain description: SAM hydroxide adenosyltransferase C-terminal domain
Occurring in:
  1. Fluorinase
The deposited structure of PDB entry 1rqp contains 3 copies of Pfam domain PF20257 (SAM hydroxide adenosyltransferase C-terminal domain) in Fluorinase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002747
Domain description: S-adenosyl-l-methionine hydroxide adenosyltransferase
Occurring in:
  1. Fluorinase
IPR023227
Domain description: S-adenosyl-l-methionine hydroxide adenosyltransferase, C-terminal domain superfamily
Occurring in:
  1. Fluorinase
IPR046469
Domain description: S-adenosyl-l-methionine hydroxide adenosyltransferase, N-terminal domain
Occurring in:
  1. Fluorinase
IPR023228
Domain description: S-adenosyl-l-methionine hydroxide adenosyltransferase, N-terminal domain superfamily
Occurring in:
  1. Fluorinase
IPR046470
Domain description: S-adenosyl-l-methionine hydroxide adenosyltransferase, C-terminal domain
Occurring in:
  1. Fluorinase
IPR030978
Domain description: Fluorinase
Occurring in:
  1. Fluorinase

Structure domains

CATH CATH domains
2.40.30.90
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Elongation Factor Tu (Ef-tu); domain 3
Homology: Bacterial fluorinating enzyme like
Occurring in:
  1. Fluorinase
The deposited structure of PDB entry 1rqp contains 3 copies of CATH domain 2.40.30.90 (Elongation Factor Tu (Ef-tu); domain 3) in Fluorinase. Showing 1 copy in chain A.
3.40.50.10790
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: S-adenosyl-l-methionine hydroxide adenosyltransferase, N-terminal
Occurring in:
  1. Fluorinase
The deposited structure of PDB entry 1rqp contains 3 copies of CATH domain 3.40.50.10790 (Rossmann fold) in Fluorinase. Showing 1 copy in chain A.
SCOP SCOP annotations
101853
Class: All beta proteins
Fold: Bacterial fluorinating enzyme, C-terminal domain
Superfamily: Bacterial fluorinating enzyme, C-terminal domain
Occurring in:
  1. Fluorinase
The deposited structure of PDB entry 1rqp contains 3 copies of SCOP domain 101853 (Bacterial fluorinating enzyme, C-terminal domain) in Fluorinase. Showing 1 copy in chain A.
102523
Class: Alpha and beta proteins (a/b)
Fold: Bacterial fluorinating enzyme, N-terminal domain
Superfamily: Bacterial fluorinating enzyme, N-terminal domain
Occurring in:
  1. Fluorinase
The deposited structure of PDB entry 1rqp contains 3 copies of SCOP domain 102523 (Bacterial fluorinating enzyme, N-terminal domain) in Fluorinase. Showing 1 copy in chain A.

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