EC 4.2.2.5: Chondroitin AC lyase
Reaction catalysed:
Eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups
Systematic name:
Chondroitin AC lyase
Alternative Name(s):
- Chondroitin AC eliminase
- Chondroitin sulfate lyase
- Chondroitinase
- Chondroitinase AC
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
PF02884
Domain description:
Polysaccharide lyase family 8, C-terminal beta-sandwich domain
Occurring in:
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1rwa</span> contains 1 copy of Pfam domain <span class='highlight'>PF02884 (Polysaccharide lyase family 8, C-terminal beta-sandwich domain)</span> in <span class='highlight'>Chondroitinase (Chondroitin lyase)</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 1rwa contains 1 copy of Pfam domain PF02884 (Polysaccharide lyase family 8, C-terminal beta-sandwich domain) in Chondroitinase (Chondroitin lyase). Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1rwa_1_A_Pfam_PF02884_image-200x200.png)
InterPro annotations
Structure domains
CATH domains
2.60.220.10
Class:
Mainly Beta
Architecture:
Sandwich
Topology:
Chondroitinase Ac; Chain A, domain 3
Homology:
Polysaccharide lyase family 8-like, C-terminal
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1rwa</span> contains 1 copy of CATH domain <span class='highlight'>2.60.220.10 (Chondroitinase Ac; Chain A, domain 3)</span> in <span class='highlight'>Chondroitinase (Chondroitin lyase)</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 1rwa contains 1 copy of CATH domain 2.60.220.10 (Chondroitinase Ac; Chain A, domain 3) in Chondroitinase (Chondroitin lyase). Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1rwa_1_A_CATH_2.60.220.10_image-200x200.png)
2.70.98.10
Class:
Mainly Beta
Architecture:
Distorted Sandwich
Topology:
Beta-galactosidase; Chain A, domain 5
Homology:
Beta-galactosidase; Chain A, domain 5
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1rwa</span> contains 1 copy of CATH domain <span class='highlight'>2.70.98.10 (Beta-galactosidase; Chain A, domain 5)</span> in <span class='highlight'>Chondroitinase (Chondroitin lyase)</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 1rwa contains 1 copy of CATH domain 2.70.98.10 (Beta-galactosidase; Chain A, domain 5) in Chondroitinase (Chondroitin lyase). Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1rwa_1_A_CATH_2.70.98.10_image-200x200.png)
SCOP annotations
49864
Class:
All beta proteins
Fold:
Hyaluronate lyase-like, C-terminal domain
Superfamily:
Hyaluronate lyase-like, C-terminal domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1rwa</span> contains 1 copy of SCOP domain <span class='highlight'>49864 (Hyaluronate lyase-like, C-terminal domain)</span> in <span class='highlight'>Chondroitinase (Chondroitin lyase)</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 1rwa contains 1 copy of SCOP domain 49864 (Hyaluronate lyase-like, C-terminal domain) in Chondroitinase (Chondroitin lyase). Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1rwa_1_A_SCOP_49864_image-200x200.png)
50006
Class:
All beta proteins
Fold:
Supersandwich
Superfamily:
Galactose mutarotase-like
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1rwa</span> contains 1 copy of SCOP domain <span class='highlight'>50006 (Hyaluronate lyase-like, central domain)</span> in <span class='highlight'>Chondroitinase (Chondroitin lyase)</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 1rwa contains 1 copy of SCOP domain 50006 (Hyaluronate lyase-like, central domain) in Chondroitinase (Chondroitin lyase). Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1rwa_1_A_SCOP_50006_image-200x200.png)
48234
Class:
All alpha proteins
Fold:
alpha/alpha toroid
Superfamily:
Chondroitin AC/alginate lyase
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1rwa</span> contains 1 copy of SCOP domain <span class='highlight'>48234 (Hyaluronate lyase-like catalytic, N-terminal domain)</span> in <span class='highlight'>Chondroitinase (Chondroitin lyase)</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 1rwa contains 1 copy of SCOP domain 48234 (Hyaluronate lyase-like catalytic, N-terminal domain) in Chondroitinase (Chondroitin lyase). Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1rwa_1_A_SCOP_48234_image-200x200.png)