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Crystal Structure of E. Coli CTP Synthetase

Source organism: Escherichia coli
Biochemical function: metal ion binding
Biological process: protein homotetramerization
Cellular component: cytoophidium

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EC 6.3.4.2: CTP synthase (glutamine hydrolyzing)

Reaction catalysed:
(1a) L-glutamine + H(2)O = L-glutamate + NH(3)
Systematic name:
UTP:L-glutamine amido-ligase (ADP-forming)
Alternative Name(s):
  • CTP synthetase
  • CTPS (gene name)
  • Cytidine 5'-triphosphate synthetase
  • Cytidine triphosphate synthetase
  • PyrG (gene name)
  • UTP--ammonia ligase
  • Uridine triphosphate aminase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF07722
Domain description: Peptidase C26
Occurring in:
  1. CTP synthase

PF00117
Domain description: Glutamine amidotransferase class-I
Occurring in:
  1. CTP synthase
The deposited structure of PDB entry 1s1m contains 2 copies of Pfam domain PF00117 (Glutamine amidotransferase class-I) in CTP synthase. Showing 1 copy in chain B.

PF06418
Domain description: CTP synthase N-terminus
Occurring in:
  1. CTP synthase
The deposited structure of PDB entry 1s1m contains 2 copies of Pfam domain PF06418 (CTP synthase N-terminus) in CTP synthase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR017456
Domain description: CTP synthase, N-terminal
Occurring in:
  1. CTP synthase
IPR004468
Domain description: CTP synthase
Occurring in:
  1. CTP synthase
IPR029062
Domain description: Class I glutamine amidotransferase-like
Occurring in:
  1. CTP synthase
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. CTP synthase
IPR017926
Domain description: Glutamine amidotransferase
Occurring in:
  1. CTP synthase
IPR033828
Domain description: CTP synthase GATase domain
Occurring in:
  1. CTP synthase

Structure domains

CATH CATH domains
3.40.50.880
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. CTP synthase
The deposited structure of PDB entry 1s1m contains 2 copies of CATH domain 3.40.50.880 (Rossmann fold) in CTP synthase. Showing 1 copy in chain B.
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. CTP synthase
The deposited structure of PDB entry 1s1m contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in CTP synthase. Showing 1 copy in chain B.
SCOP SCOP annotations
52318
Class: Alpha and beta proteins (a/b)
Fold: Flavodoxin-like
Superfamily: Class I glutamine amidotransferase-like
Occurring in:
  1. CTP synthase
The deposited structure of PDB entry 1s1m contains 2 copies of SCOP domain 52318 (Class I glutamine amidotransferases (GAT)) in CTP synthase. Showing 1 copy in chain B.
52652
Class: Alpha and beta proteins (a/b)
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Occurring in:
  1. CTP synthase
The deposited structure of PDB entry 1s1m contains 2 copies of SCOP domain 52652 (Nitrogenase iron protein-like) in CTP synthase. Showing 1 copy in chain B.

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