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CRYSTAL STRUCTURE OF FIBROBLAST STROMELYSIN-1: THE C-TRUNCATED HUMAN PROENZYME

Source organism: Homo sapiens
Biochemical function: zinc ion binding
Biological process: proteolysis
Cellular component: extracellular matrix

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EC 3.4.24.17: Stromelysin 1

Reaction catalysed:
Preferential cleavage where P1', P2' and P3' are hydrophobic residues.
Alternative Name(s):
  • Collagen-activating protein
  • Collagenase activating protein
  • MMP-3
  • Matrix metalloproteinase 3
  • Neutral proteoglycanase
  • Procollagenase activator
  • Proteoglycanase
  • Stromelysin
  • Transin

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00413
Domain description: Matrixin
Occurring in:
  1. Stromelysin-1
The deposited structure of PDB entry 1slm contains 1 copy of Pfam domain PF00413 (Matrixin) in Stromelysin-1. Showing 1 copy in chain A.

PF01471
Domain description: Putative peptidoglycan binding domain
Occurring in:
  1. Stromelysin-1
The deposited structure of PDB entry 1slm contains 1 copy of Pfam domain PF01471 (Putative peptidoglycan binding domain) in Stromelysin-1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR021190
Domain description: Peptidase M10A
Occurring in:
  1. Stromelysin-1
IPR033739
Domain description: Peptidase M10A, catalytic domain
Occurring in:
  1. Stromelysin-1
IPR001818
Domain description: Peptidase M10, metallopeptidase
Occurring in:
  1. Stromelysin-1
IPR006026
Domain description: Peptidase, metallopeptidase
Occurring in:
  1. Stromelysin-1
IPR021158
Domain description: Peptidase M10A, cysteine switch, zinc binding site
Occurring in:
  1. Stromelysin-1
IPR036365
Domain description: PGBD-like superfamily
Occurring in:
  1. Stromelysin-1
IPR002477
Domain description: Peptidoglycan binding-like
Occurring in:
  1. Stromelysin-1
IPR024079
Domain description: Metallopeptidase, catalytic domain superfamily
Occurring in:
  1. Stromelysin-1

Structure domain

CATH CATH domain
3.40.390.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Collagenase (Catalytic Domain)
Homology: Collagenase (Catalytic Domain)
Occurring in:
  1. Stromelysin-1
The deposited structure of PDB entry 1slm contains 1 copy of CATH domain 3.40.390.10 (Collagenase (Catalytic Domain)) in Stromelysin-1. Showing 1 copy in chain A.
SCOP SCOP annotations
55528
Class: Alpha and beta proteins (a+b)
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Occurring in:
  1. Stromelysin-1
The deposited structure of PDB entry 1slm contains 1 copy of SCOP domain 55528 (Matrix metalloproteases, catalytic domain) in Stromelysin-1. Showing 1 copy in chain A.
63427
Class: All alpha proteins
Fold: PGBD-like
Superfamily: PGBD-like
Occurring in:
  1. Stromelysin-1
The deposited structure of PDB entry 1slm contains 1 copy of SCOP domain 63427 (MMP N-terminal domain) in Stromelysin-1. Showing 1 copy in chain A.

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