› 1sm3

X-ray diffraction
1.95Å resolution

CRYSTAL STRUCTURE OF THE TUMOR SPECIFIC ANTIBODY SM3 COMPLEX WITH ITS PEPTIDE EPITOPE

Released:
DOI: 10.2210/pdb1sm3/pdb
PDB entry 1sm3 coloured by chain, front view.
PDB entry 1sm3 coloured by chain, side view.
PDB entry 1sm3 coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure at 1.95 A resolution of the breast tumour-specific antibody SM3 complexed with its peptide epitope reveals novel hypervariable loop recognition.
Dokurno P, Bates PA, Band HA, Stewart LM, Lally JM, Burchell JM, Taylor-Papadimitriou J, Snary D, Sternberg MJ, Freemont PS
J Mol Biol 284 713-28 (1998)
PMID: 9826510

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-134498 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig lambda-1 chain V region Chain: L
Molecule details ›
Chain: L
Length: 215 amino acids
Theoretical weight: 23.15 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P01723 (Residues: 23-117; Coverage: 98%)
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins
Ig heavy chain V-III region J606 Chain: H
Molecule details ›
Chain: H
Length: 218 amino acids
Theoretical weight: 23.46 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P01801 (Residues: 1-58, 60-100, 101-101, 102-115; Coverage: 99%)
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins
Mucin-1 subunit alpha Chain: P
Molecule details ›
Chain: P
Length: 13 amino acids
Theoretical weight: 1.26 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P15941 (Residues: 919-931; Coverage: 1%)
Gene names: MUC1, PUM

Ligands and Environments

2 bound ligands:
Ligand CD 8 x CD
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P21
Unit cell:
a: 42.2Å b: 83.73Å c: 67.24Å
α: 90° β: 93.3° γ: 90°
R-values:
R R work R free
0.213 0.213 0.283
Expression system: Not provided

Quick links

Citations

8 review citations

An overview of toxins and genes from the venom of the Asian scorpion Buthus martensi Karsch.
Goudet et al. (2002)
7 more

10 mentions without citation

Neutralizing ebolavirus: structural insights into the envelope glycoprotein and antibodies targeted against it.
Lee et al. (2009)
9 more