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Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A.

Kelker MS, Foss TR, Peti W, Teyton L, Kelly JW, Wüthrich K, Wilson IA
J Mol Biol 342 1237-48 (2004)
Cited: 43 times
EuropePMC logo PMID: 15351648

Abstract

The triggering receptor expressed on myeloid cells (TREM) family of single extracellular immunoglobulin receptors includes both activating and inhibitory isoforms whose ligands are unknown. TREM-1 activation amplifies the Toll-like receptor initiated responses to invading pathogens allowing the secretion of pro-inflammatory chemokines and cytokines. Hence, TREM-1 amplifies the inflammation induced by both bacteria and fungi, and thus represents a potential therapeutic target. We report the crystal structure of the human TREM-1 extracellular domain at 1.47 A resolution. The overall fold places it within the V-type immunoglobulin domain family and reveals close homology with Ig domains from antibodies, T-cell receptors and other activating receptors, such as NKp44. With the additional use of analytical ultracentrifugation and 1H NMR spectroscopy of both human and mouse TREM-1, we have conclusively demonstrated the monomeric state of this extracellular ectodomain in solution and, presumably, of the TREM family in general.

Articles - 1smo mentioned but not cited (6)

  1. Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms. Kober DL, Alexander-Brett JM, Karch CM, Cruchaga C, Colonna M, Holtzman MJ, Brett TJ. Elife 5 (2016)
  2. Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseases. Kober DL, Wanhainen KM, Johnson BM, Randolph DT, Holtzman MJ, Brett TJ. Protein Expr. Purif. 96 32-38 (2014)
  3. Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2. Sudom A, Talreja S, Danao J, Bragg E, Kegel R, Min X, Richardson J, Zhang Z, Sharkov N, Marcora E, Thibault S, Bradley J, Wood S, Lim AC, Chen H, Wang S, Foltz IN, Sambashivan S, Wang Z. J. Biol. Chem. 293 12634-12646 (2018)
  4. Impaired lipophagy induced-microglial lipid droplets accumulation contributes to the buildup of TREM1 in diabetes-associated cognitive impairment. Li Q, Zhao Y, Guo H, Li Q, Yan C, Li Y, He S, Wang N, Wang Q. Autophagy 19 2639-2656 (2023)
  5. The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins. Chakraborty S, Rendón-Ramírez A, Ásgeirsson B, Dutta M, Ghosh AS, Oda M, Venkatramani R, Rao BJ, Dandekar AM, Goñi FM. F1000Res 2 286 (2013)
  6. The CDR3 region as the major driver of TREM-1 interaction with its ligands, an in silico characterization. de Oliveira Matos A, Dos Santos Dantas PH, Colmenares MTC, Sartori GR, Silva-Sales M, Da Silva JHM, Neves BJ, Andrade CH, Sales-Campos H. Comput Struct Biotechnol J 21 2579-2590 (2023)


Reviews citing this publication (15)

  1. The TREM receptor family and signal integration. Klesney-Tait J, Turnbull IR, Colonna M. Nat. Immunol. 7 1266-1273 (2006)
  2. The TREM-1/DAP12 pathway. Tessarz AS, Cerwenka A. Immunol. Lett. 116 111-116 (2008)
  3. TREM2, Microglia, and Neurodegenerative Diseases. Yeh FL, Hansen DV, Sheng M. Trends Mol Med 23 512-533 (2017)
  4. Triggering receptor expressed on myeloid cells-1 (TREM-1): a new player in antiviral immunity? Roe K, Gibot S, Verma S. Front Microbiol 5 627 (2014)
  5. Triggering receptor expressed on myeloid cells receptor family modulators: a patent review. Pelham CJ, Pandya AN, Agrawal DK. Expert Opin Ther Pat 24 1383-1395 (2014)
  6. Triggering receptor expressed on myeloid cells type 1 as a potential therapeutic target in sepsis. Palazzo SJ, Simpson T, Schnapp LM. Dimens Crit Care Nurs 31 1-6 (2012)
  7. The Role of APOE and TREM2 in Alzheimer's Disease-Current Understanding and Perspectives. Wolfe CM, Fitz NF, Nam KN, Lefterov I, Koldamova R. Int J Mol Sci 20 (2018)
  8. Novel ligands and modulators of triggering receptor expressed on myeloid cells receptor family: 2015-2020 updates. Singh H, Rai V, Nooti SK, Agrawal DK. Expert Opin Ther Pat 31 549-561 (2021)
  9. The biology of TREM receptors. Colonna M. Nat Rev Immunol (2023)
  10. Targeting Mononuclear Phagocyte Receptors in Cancer Immunotherapy: New Perspectives of the Triggering Receptor Expressed on Myeloid Cells (TREM-1). Raggi F, Bosco MC. Cancers (Basel) 12 (2020)
  11. The orchestrating role of deteriorating neurons and TREM-1 in crosstalk with SYK in Alzheimer's disease progression and neuroinflammation. Anwar MM. Inflammopharmacology (2023)
  12. The role of triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases. Zhang C, Kan X, Zhang B, Ni H, Shao J. Mol Brain 15 84 (2022)
  13. Triggering Receptor Expressed on Myeloid Cells-1 Signaling: Protective and Pathogenic Roles on Streptococcal Toxic-Shock-Like Syndrome Caused by Streptococcus suis. Han L, Fu L, Peng Y, Zhang A. Front Immunol 9 577 (2018)
  14. Triggering receptor expressed on myeloid cells-1 in sepsis, and current insights into clinical studies. Theobald V, Schmitt FCF, Middel CS, Gaissmaier L, Brenner T, Weigand MA. Crit Care 28 17 (2024)
  15. [Blockade of Triggering receptor expressed on myeloid cells-1 as a new therapy of arthritis]. Iwai H, Kohsaka H. Nihon Rinsho Meneki Gakkai Kaishi 35 81-86 (2012)

Articles citing this publication (22)

  1. TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Yeh FL, Wang Y, Tom I, Gonzalez LC, Sheng M. Neuron 91 328-340 (2016)
  2. Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors. Netea MG, Azam T, Ferwerda G, Girardin SE, Kim SH, Dinarello CA. J. Leukoc. Biol. 80 1454-1461 (2006)
  3. Modulation of the triggering receptor expressed on the myeloid cell type 1 pathway in murine septic shock. Gibot S, Buonsanti C, Massin F, Romano M, Kolopp-Sarda MN, Benigni F, Faure GC, Béné MC, Panina-Bordignon P, Passini N, Lévy B. Infect. Immun. 74 2823-2830 (2006)
  4. Soluble TREM-like transcript-1 regulates leukocyte activation and controls microbial sepsis. Derive M, Bouazza Y, Sennoun N, Marchionni S, Quigley L, Washington V, Massin F, Max JP, Ford J, Alauzet C, Levy B, McVicar DW, Gibot S. J. Immunol. 188 5585-5592 (2012)
  5. The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment. Gattis JL, Washington AV, Chisholm MM, Quigley L, Szyk A, McVicar DW, Lubkowski J. J. Biol. Chem. 281 13396-13403 (2006)
  6. TREM-1 Exacerbates Neuroinflammatory Injury via NLRP3 Inflammasome-Mediated Pyroptosis in Experimental Subarachnoid Hemorrhage. Xu P, Hong Y, Xie Y, Yuan K, Li J, Sun R, Zhang X, Shi X, Li R, Wu J, Liu X, Hu W, Sun W. Transl Stroke Res 12 643-659 (2021)
  7. Triggering receptor expressed on myeloid cells-1 as a new therapeutic target during inflammatory diseases. Derive M, Massin F, Gibot S. Self Nonself 1 225-230 (2010)
  8. Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.76 A. Kelker MS, Debler EW, Wilson IA. J. Mol. Biol. 344 1175-1181 (2004)
  9. TREM-1 expression is increased in human placentas from severe early-onset preeclamptic pregnancies where it may be involved in syncytialization. Lim R, Barker G, Lappas M. Reprod Sci 21 562-572 (2014)
  10. The crystal structure of the extracellular domain of the inhibitor receptor expressed on myeloid cells IREM-1. Márquez JA, Galfré E, Dupeux F, Flot D, Moran O, Dimasi N. J. Mol. Biol. 367 310-318 (2007)
  11. Simplified large-scale refolding, purification, and characterization of recombinant human granulocyte-colony stimulating factor in Escherichia coli. Kim CK, Lee CH, Lee SB, Oh JW. PLoS ONE 8 e80109 (2013)
  12. Soluble triggering receptor expressed on myeloid cells-1 as an infection marker for patients with neutropenic fever. Lin CH, Yao M, Hsu SC, Ho CC, Lin MT, Lin CA, Hu FC, Yu CJ, Tien HF. Crit. Care Med. 39 993-999 (2011)
  13. Structural characterization of the neurabin sterile alpha motif domain. Ju T, Ragusa MJ, Hudak J, Nairn AC, Peti W. Proteins 69 192-198 (2007)
  14. Expression and purification of recombinant human granulocyte colony-stimulating factor in fed-batch culture of Escherichia coli. Kim CK, Choi JH, Lee SB, Lee SM, Oh JW. Appl. Biochem. Biotechnol. 172 2425-2435 (2014)
  15. Hsp70 Interacts with the TREM-1 Receptor Expressed on Monocytes and Thereby Stimulates Generation of Cytotoxic Lymphocytes Active against MHC-Negative Tumor Cells. Sharapova TN, Romanova EA, Ivanova OK, Yashin DV, Sashchenko LP. Int J Mol Sci 22 6889 (2021)
  16. TREM-1 multimerization is essential for its activation on monocytes and neutrophils. Carrasco K, Boufenzer A, Jolly L, Le Cordier H, Wang G, Heck AJ, Cerwenka A, Vinolo E, Nazabal A, Kriznik A, Launay P, Gibot S, Derive M. Cell. Mol. Immunol. 16 460-472 (2019)
  17. LR12-peptide quantitation in whole blood by RP-HPLC and intrinsic fluorescence detection: Validation and pharmacokinetic study. Parent M, Boudier A, Maincent P, Gibot S, Ait-Oufella H, Boufenzer A, Jolly L, Derive M, Kouach M, Goossens JF, Leroy P, Clarot I. Biomed. Chromatogr. 31 (2017)
  18. TREM1 regulates antifungal immune responses in invasive pulmonary aspergillosis. Bernal-Martínez L, Gonçalves SM, de Andres B, Cunha C, Gonzalez Jimenez I, Lagrou K, Mellado E, Gaspar ML, Maertens JA, Carvalho A, Alcazar-Fuoli L. Virulence 12 570-583 (2021)
  19. CRDSAT Generated by pCARGHO: A New Efficient Lectin-Based Affinity Tag Method for Safe, Simple, and Low-Cost Protein Purification. Kriznik A, Yéléhé-Okouma M, Lec JC, Groshenry G, Le Cordier H, Charron C, Quinternet M, Mazon H, Talfournier F, Boschi-Muller S, Jouzeau JY, Reboul P. Biotechnol J 14 e1800214 (2019)
  20. Pan-cancer structurome reveals overrepresentation of beta sandwiches and underrepresentation of alpha helical domains. Medvedev KE, Schaeffer RD, Chen KS, Grishin NV. Sci Rep 13 11988 (2023)
  21. Persistently Elevated Soluble Triggering Receptor Expressed on Myeloid Cells 1 and Decreased Monocyte Human Leucocyte Antigen DR Expression Are Associated With Nosocomial Infections in Septic Shock Patients. Venet M, Bidar F, Derive M, Delwarde B, Monard C, Hengy B, Jolly L, Rimmelé T, Lukaszewicz AC, Monneret G, Venet F. Crit Care Explor 5 e0869 (2023)
  22. The identification, characterization, and function of two TREMs genes in Chinese Yangzhou goose (Anas cygnoides). Zhu H, Liu X, Du J, Lei M, Ying S, Yan J, Yu J, Shi Z, Li H. Dev. Comp. Immunol. 73 131-138 (2017)


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