› 1t4j

X-ray diffraction
2.7Å resolution

Allosteric Inhibition of Protein Tyrosine Phosphatase 1B

Released:
DOI: 10.2210/pdb1t4j/pdb
PDB entry 1t4j coloured by chain, front view.
PDB entry 1t4j coloured by chain, side view.
PDB entry 1t4j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Allosteric inhibition of protein tyrosine phosphatase 1B.
Wiesmann C, Barr KJ, Kung J, Zhu J, Erlanson DA, Shen W, Fahr BJ, Zhong M, Taylor L, Randal M, McDowell RS, Hansen SK
Nat Struct Mol Biol 11 730-7 (2004)
PMID: 15258570

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148259 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 1 Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 34.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P18031 (Residues: 1-298; Coverage: 69%)
Gene names: PTP1B, PTPN1
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:
Ligand FRJ 1 x FRJ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P3121
Unit cell:
a: 88.544Å b: 88.544Å c: 104.828Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.229 0.228 0.246
Expression system: Escherichia coli

Quick links

Citations

37 review citations

Protein tyrosine phosphatases: from genes, to function, to disease.
Tonks NK. (2006)
36 more

18 mentions without citation

Human Protein Tyrosine Phosphatase 1B (PTP1B): From Structure to Clinical Inhibitor Perspectives.
Liu et al. (2022)
17 more