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Crystal structure of C205F mutant of PKS18 from Mycobacterium tuberculosis

Source organism: Mycobacterium tuberculosis H37Rv
Biochemical function: acyltransferase activity, transferring groups other than amino-acyl groups
Biological process: polyketide biosynthetic process
Cellular component: not assigned

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF02797
Domain description: Chalcone and stilbene synthases, C-terminal domain
Occurring in:
  1. Alpha-pyrone synthesis polyketide synthase-like Pks18
The deposited structure of PDB entry 1tee contains 4 copies of Pfam domain PF02797 (Chalcone and stilbene synthases, C-terminal domain) in Alpha-pyrone synthesis polyketide synthase-like Pks18. Showing 1 copy in chain A.

PF00195
Domain description: Chalcone and stilbene synthases, N-terminal domain
Occurring in:
  1. Alpha-pyrone synthesis polyketide synthase-like Pks18
The deposited structure of PDB entry 1tee contains 4 copies of Pfam domain PF00195 (Chalcone and stilbene synthases, N-terminal domain) in Alpha-pyrone synthesis polyketide synthase-like Pks18. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016039
Domain description: Thiolase-like
Occurring in:
  1. Alpha-pyrone synthesis polyketide synthase-like Pks18
IPR011141
Domain description: Polyketide synthase, type III
Occurring in:
  1. Alpha-pyrone synthesis polyketide synthase-like Pks18
IPR012328
Domain description: Chalcone/stilbene synthase, C-terminal
Occurring in:
  1. Alpha-pyrone synthesis polyketide synthase-like Pks18
IPR001099
Domain description: Chalcone/stilbene synthase, N-terminal
Occurring in:
  1. Alpha-pyrone synthesis polyketide synthase-like Pks18

Structure domain

CATH CATH domain
3.40.47.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Peroxisomal Thiolase; Chain A, domain 1
Homology: Peroxisomal Thiolase; Chain A, domain 1
Occurring in:
  1. Alpha-pyrone synthesis polyketide synthase-like Pks18
The deposited structure of PDB entry 1tee contains 8 copies of CATH domain 3.40.47.10 (Peroxisomal Thiolase; Chain A, domain 1) in Alpha-pyrone synthesis polyketide synthase-like Pks18. Showing 2 copies in chain A.
SCOP SCOP annotation
53914
Class: Alpha and beta proteins (a/b)
Fold: Thiolase-like
Superfamily: Thiolase-like
Occurring in:
  1. Alpha-pyrone synthesis polyketide synthase-like Pks18
The deposited structure of PDB entry 1tee contains 4 copies of SCOP domain 53914 (Chalcone synthase-like) in Alpha-pyrone synthesis polyketide synthase-like Pks18. Showing 1 copy in chain A.

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