› 1tgx

X-ray diffraction
1.55Å resolution

X-RAY STRUCTURE AT 1.55 A OF TOXIN GAMMA, A CARDIOTOXIN FROM NAJA NIGRICOLLIS VENOM. CRYSTAL PACKING REVEALS A MODEL FOR INSERTION INTO MEMBRANES

Released:
DOI: 10.2210/pdb1tgx/pdb
PDB entry 1tgx coloured by chain, front view.
PDB entry 1tgx coloured by chain, side view.
PDB entry 1tgx coloured by chain, top view.
Source organism: Naja nigricollis
Primary publication:
X-ray structure at 1.55 A of toxin gamma, a cardiotoxin from Naja nigricollis venom. Crystal packing reveals a model for insertion into membranes.
Bilwes A, Rees B, Moras D, Ménez R, Ménez A
J Mol Biol 239 122-36 (1994)
PMID: 8196041

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134323 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytotoxin 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 60 amino acids
Theoretical weight: 6.84 KDa
Source organism: Naja nigricollis
Expression system: Not provided
UniProt:
  • Canonical: P01468 (Residues: 1-60; Coverage: 100%)
Sequence domains: Snake toxin cobra-type
Structure domains: CD59

Ligands and Environments

1 bound ligand:
Ligand CL 14 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 78.67Å b: 40.71Å c: 56.02Å
α: 90° β: 117.08° γ: 90°
R-values:
R R work R free
0.172 0.172 not available
Expression system: Not provided

Quick links

Citations

7 review citations

Snake venom alpha-neurotoxins and other 'three-finger' proteins.
Tsetlin V. (1999)
6 more

9 mentions without citation

Specific Amino Acid Residues in the Three Loops of Snake Cytotoxins Determine Their Membrane Activity and Provide a Rationale for a New Classification of These Toxins.
Dubovskii et al. (2024)
8 more