› 1tlm

X-ray diffraction
1.9Å resolution

STRUCTURAL ASPECTS OF INOTROPIC BIPYRIDINE BINDING: CRYSTAL STRUCTURE DETERMINATION TO 1.9 ANGSTROMS OF THE HUMAN SERUM TRANSTHYRETIN-MILRINONE COMPLEX

Released:
DOI: 10.2210/pdb1tlm/pdb
PDB entry 1tlm coloured by chain, front view.
PDB entry 1tlm coloured by chain, side view.
PDB entry 1tlm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural aspects of inotropic bipyridine binding. Crystal structure determination to 1.9 A of the human serum transthyretin-milrinone complex.
Wojtczak A, Luft JR, Cody V
J Biol Chem 268 6202-6 (1993)
PMID: 8454595

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand MIL 2 x MIL
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21212
Unit cell:
a: 44.178Å b: 86.384Å c: 66.212Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 not available not available
Expression system: Not provided

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Citations

4 review citations

Nitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophore.
Fleming et al. (2010)
3 more