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Triple mutation in interleukin 1 beta cavity:replacement of phenylalanines with tryptophan.

Source organism: Homo sapiens
Biochemical function: cytokine activity
Biological process: immune response
Cellular component: extracellular space

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00340
Domain description: Interleukin-1 / 18
Occurring in:
  1. Interleukin-1 beta
The deposited structure of PDB entry 1tp0 contains 1 copy of Pfam domain PF00340 (Interleukin-1 / 18) in Interleukin-1 beta. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000975
Domain description: Interleukin-1 family
Occurring in:
  1. Interleukin-1 beta
IPR020877
Domain description: Interleukin-1 conserved site
Occurring in:
  1. Interleukin-1 beta
IPR008996
Domain description: Cytokine IL1/FGF
Occurring in:
  1. Interleukin-1 beta

Structure domain

CATH CATH domain
2.80.10.50
Class: Mainly Beta
Architecture: Trefoil
Topology: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Homology: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Occurring in:
  1. Interleukin-1 beta
The deposited structure of PDB entry 1tp0 contains 1 copy of CATH domain 2.80.10.50 (Trefoil (Acidic Fibroblast Growth Factor, subunit A)) in Interleukin-1 beta. Showing 1 copy in chain A.

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