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SOLUTION STRUCTURE OF THE FIBRIN BINDING FINGER DOMAIN OF TISSUE-TYPE PLASMINOGEN ACTIVATOR DETERMINED BY 1H NUCLEAR MAGNETIC RESONANCE

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: extracellular region

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EC 3.4.21.68: T-plasminogen activator

Reaction catalysed:
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
Systematic name:
-
Alternative Name(s):
  • Plasminogen activator, tissue-type
  • T-PA
  • Tissue plasminogen activator
  • Tissue-type plasminogen activator
  • tPA

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00039
Domain description: Fibronectin type I domain
Occurring in:
  1. Tissue-type plasminogen activator chain A
The deposited structure of PDB entry 1tpn contains 1 copy of Pfam domain PF00039 (Fibronectin type I domain) in Tissue-type plasminogen activator chain A. Showing 1 copy in chain A.

InterPro InterPro annotation
IPR000083
Domain description: Fibronectin, type I
Occurring in:
  1. Tissue-type plasminogen activator chain A

Structure domain

CATH CATH domain
2.10.70.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Complement Module; domain 1
Homology: Complement Module, domain 1
Occurring in:
  1. Tissue-type plasminogen activator chain A
The deposited structure of PDB entry 1tpn contains 1 copy of CATH domain 2.10.70.10 (Complement Module; domain 1) in Tissue-type plasminogen activator chain A. Showing 1 copy in chain A.
SCOP SCOP annotation
57604
Class: Small proteins
Fold: FnI-like domain
Superfamily: FnI-like domain
Occurring in:
  1. Tissue-type plasminogen activator chain A
The deposited structure of PDB entry 1tpn contains 1 copy of SCOP domain 57604 (Fibronectin type I module) in Tissue-type plasminogen activator chain A. Showing 1 copy in chain A.

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