› › Function and Biology

STructure of Onchoverca volvulus Pi-class Glutathione S-transferase with its kompetitive inhibitor s-hexyl-GSH

Source organism: Onchocerca volvulus
Biochemical function: transferase activity
Biological process: glutathione metabolic process
Cellular component: cytosol

Quick links

EC 2.5.1.18: Glutathione transferase

Reaction catalysed:
RX + glutathione = HX + R-S-glutathione
Systematic name:
RX:glutathione R-transferase
Alternative Name(s):
  • Glutathione S-alkyl transferase
  • Glutathione S-alkyltransferase
  • Glutathione S-aralkyltransferase
  • Glutathione S-aryltransferase
  • Glutathione S-transferase
  • S-(hydroxyalkyl)glutathione lyase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF14497
Domain description: Glutathione S-transferase, C-terminal domain
Occurring in:
  1. Glutathione S-transferase 2
The deposited structure of PDB entry 1tu8 contains 4 copies of Pfam domain PF14497 (Glutathione S-transferase, C-terminal domain) in Glutathione S-transferase 2. Showing 1 copy in chain A.

PF02798
Domain description: Glutathione S-transferase, N-terminal domain
Occurring in:
  1. Glutathione S-transferase 2
The deposited structure of PDB entry 1tu8 contains 4 copies of Pfam domain PF02798 (Glutathione S-transferase, N-terminal domain) in Glutathione S-transferase 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003082
Domain description: Glutathione S-transferase, Pi class
Occurring in:
  1. Glutathione S-transferase 2
IPR004045
Domain description: Glutathione S-transferase, N-terminal
Occurring in:
  1. Glutathione S-transferase 2
IPR004046
Domain description: Glutathione S-transferase, C-terminal
Occurring in:
  1. Glutathione S-transferase 2
IPR010987
Domain description: Glutathione S-transferase, C-terminal-like
Occurring in:
  1. Glutathione S-transferase 2
IPR036282
Domain description: Glutathione S-transferase, C-terminal domain superfamily
Occurring in:
  1. Glutathione S-transferase 2
IPR036249
Domain description: Thioredoxin-like superfamily
Occurring in:
  1. Glutathione S-transferase 2

Structure domains

CATH CATH domains
3.40.30.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Glutaredoxin
Homology: Glutaredoxin
Occurring in:
  1. Glutathione S-transferase 2
The deposited structure of PDB entry 1tu8 contains 4 copies of CATH domain 3.40.30.10 (Glutaredoxin) in Glutathione S-transferase 2. Showing 1 copy in chain A.
1.20.1050.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
Homology: Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
Occurring in:
  1. Glutathione S-transferase 2
The deposited structure of PDB entry 1tu8 contains 4 copies of CATH domain 1.20.1050.10 (Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2) in Glutathione S-transferase 2. Showing 1 copy in chain A.
SCOP SCOP annotations
47617
Class: All alpha proteins
Fold: GST C-terminal domain-like
Superfamily: GST C-terminal domain-like
Occurring in:
  1. Glutathione S-transferase 2
The deposited structure of PDB entry 1tu8 contains 4 copies of SCOP domain 47617 (Glutathione S-transferase (GST), C-terminal domain) in Glutathione S-transferase 2. Showing 1 copy in chain A.
52862
Class: Alpha and beta proteins (a/b)
Fold: Thioredoxin fold
Superfamily: Thioredoxin-like
Occurring in:
  1. Glutathione S-transferase 2
The deposited structure of PDB entry 1tu8 contains 4 copies of SCOP domain 52862 (Glutathione S-transferase (GST), N-terminal domain) in Glutathione S-transferase 2. Showing 1 copy in chain A.

Quick links