› 1txf

X-ray diffraction
2.1Å resolution

CRYSTAL STRUCTURE OF THE GLUR5 LIGAND BINDING CORE IN COMPLEX WITH GLUTAMATE AT 2.1 ANGSTROM RESOLUTION

Released:
DOI: 10.2210/pdb1txf/pdb
PDB entry 1txf coloured by chain, front view.
PDB entry 1txf coloured by chain, side view.
PDB entry 1txf coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivity.
Mayer ML
Neuron 45 539-52 (2005)
PMID: 15721240

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149793 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 1 Chain: A
Molecule details ›
Chain: A
Length: 258 amino acids
Theoretical weight: 29.25 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P22756 (Residues: 446-559, 682-821; Coverage: 28%)
Gene names: Glur5, Grik1
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand GLU 1 x GLU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 119.809Å b: 63.71Å c: 50.354Å
α: 90° β: 107.22° γ: 90°
R-values:
R R work R free
0.222 0.219 0.25
Expression system: Escherichia coli

Quick links

Citations

39 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
38 more

7 mentions without citation

Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.
Mayer et al. (2006)
6 more