1u38 › Citations

Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem.

Long JF, Feng W, Wang R, Chan LN, Ip FC, Xia J, Ip NY, Zhang M
Nat Struct Mol Biol 12 722-8 (2005)
Related entries: 1u37, 1u39, 1u3b

Cited: 53 times
EuropePMC logo PMID: 16007100

Abstract

Members of the X11/Mint family of multidomain adaptor proteins are composed of a divergent N terminus, a conserved PTB domain and a pair of C-terminal PDZ domains. Many proteins can interact with the PDZ tandem of X11 proteins, although the mechanism of such interactions is unclear. Here we show that the highly conserved C-terminal tail of X11alpha folds back and inserts into the target-binding groove of the first PDZ domain. The binding of this tail occludes the binding of other target peptides. This autoinhibited conformation of X11 requires that the two PDZ domains and the entire C-terminal tail be covalently connected to form an integral structural unit. The autoinhibited conformation of the X11 PDZ tandem provides a mechanistic explanation for the unique target-binding properties of the protein and hints at potential regulatory mechanisms for the X11-target interactions.

Articles - 1u38 mentioned but not cited (1)

  1. Putting into practice domain-linear motif interaction predictions for exploration of protein networks. Luck K, Fournane S, Kieffer B, Masson M, Nominé Y, Travé G. PLoS One 6 e25376 (2011)


Reviews citing this publication (13)

  1. Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density. Feng W, Zhang M. Nat Rev Neurosci 10 87-99 (2009)
  2. Dynamic control of signaling by modular adaptor proteins. Pawson T. Curr Opin Cell Biol 19 112-116 (2007)
  3. Structures and target recognition modes of PDZ domains: recurring themes and emerging pictures. Ye F, Zhang M. Biochem J 455 1-14 (2013)
  4. Conditionally and transiently disordered proteins: awakening cryptic disorder to regulate protein function. Jakob U, Kriwacki R, Uversky VN. Chem Rev 114 6779-6805 (2014)
  5. Plasticity of PDZ domains in ligand recognition and signaling. Ivarsson Y. FEBS Lett 586 2638-2647 (2012)
  6. The emerging contribution of sequence context to the specificity of protein interactions mediated by PDZ domains. Luck K, Charbonnier S, Travé G. FEBS Lett 586 2648-2661 (2012)
  7. The X11/Mint family of adaptor proteins. Rogelj B, Mitchell JC, Miller CC, McLoughlin DM. Brain Res Rev 52 305-315 (2006)
  8. PDZ Domains as Drug Targets. Christensen NR, Čalyševa J, Fernandes EFA, Lüchow S, Clemmensen LS, Haugaard-Kedström LM, Strømgaard K. Adv Ther (Weinh) 2 1800143 (2019)
  9. Structural diversity of PDZ-lipid interactions. Gallardo R, Ivarsson Y, Schymkowitz J, Rousseau F, Zimmermann P. Chembiochem 11 456-467 (2010)
  10. Synaptic transmission regulated by a presynaptic MALS/Liprin-alpha protein complex. Olsen O, Moore KA, Nicoll RA, Bredt DS. Curr Opin Cell Biol 18 223-227 (2006)
  11. Synapse formation and remodeling. Luo Z. Sci China Life Sci 53 315-321 (2010)
  12. Scaffold proteins as dynamic integrators of biological processes. DiRusso CJ, Dashtiahangar M, Gilmore TD. J Biol Chem 298 102628 (2022)
  13. Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer. Nardella C, Visconti L, Malagrinò F, Pagano L, Bufano M, Nalli M, Coluccia A, La Regina G, Silvestri R, Gianni S, Toto A. Biol Direct 16 15 (2021)

Articles citing this publication (39)

  1. PDZ domains and their binding partners: structure, specificity, and modification. Lee HJ, Zheng JJ. Cell Commun Signal 8 8 (2010)
  2. PDZ domains of Par-3 as potential phosphoinositide signaling integrators. Wu H, Feng W, Chen J, Chan LN, Huang S, Zhang M. Mol Cell 28 886-898 (2007)
  3. Disruption of KIF17-Mint1 interaction by CaMKII-dependent phosphorylation: a molecular model of kinesin-cargo release. Guillaud L, Wong R, Hirokawa N. Nat Cell Biol 10 19-29 (2008)
  4. Syntenin-1 is a new component of tetraspanin-enriched microdomains: mechanisms and consequences of the interaction of syntenin-1 with CD63. Latysheva N, Muratov G, Rajesh S, Padgett M, Hotchin NA, Overduin M, Berditchevski F. Mol Cell Biol 26 7707-7718 (2006)
  5. The structure of the harmonin/sans complex reveals an unexpected interaction mode of the two Usher syndrome proteins. Yan J, Pan L, Chen X, Wu L, Zhang M. Proc Natl Acad Sci U S A 107 4040-4045 (2010)
  6. Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes. Pan L, Wu H, Shen C, Shi Y, Jin W, Xia J, Zhang M. EMBO J 26 4576-4587 (2007)
  7. Identification of specificity and promiscuity of PDZ domain interactions through their dynamic behavior. Gerek ZN, Keskin O, Ozkan SB. Proteins 77 796-811 (2009)
  8. Domain swapping within PDZ2 is responsible for dimerization of ZO proteins. Fanning AS, Lye MF, Anderson JM, Lavie A. J Biol Chem 282 37710-37716 (2007)
  9. Structural and functional studies of EpsC, a crucial component of the type 2 secretion system from Vibrio cholerae. Korotkov KV, Krumm B, Bagdasarian M, Hol WG. J Mol Biol 363 311-321 (2006)
  10. The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye. Liu W, Wen W, Wei Z, Yu J, Ye F, Liu CH, Hardie RC, Zhang M. Cell 145 1088-1101 (2011)
  11. Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation. Sugi T, Oyama T, Muto T, Nakanishi S, Morikawa K, Jingami H. EMBO J 26 2192-2205 (2007)
  12. Identifying weak interdomain interactions that stabilize the supertertiary structure of the N-terminal tandem PDZ domains of PSD-95. Yanez Orozco IS, Mindlin FA, Ma J, Wang B, Levesque B, Spencer M, Rezaei Adariani S, Hamilton G, Ding F, Bowen ME, Sanabria H. Nat Commun 9 3724 (2018)
  13. The scaffold protein PDZK1 undergoes a head-to-tail intramolecular association that negatively regulates its interaction with EBP50. LaLonde DP, Bretscher A. Biochemistry 48 2261-2271 (2009)
  14. Structural basis of beta-catenin recognition by Tax-interacting protein-1. Zhang J, Yan X, Shi C, Yang X, Guo Y, Tian C, Long J, Shen Y. J Mol Biol 384 255-263 (2008)
  15. Mint proteins are required for synaptic activity-dependent amyloid precursor protein (APP) trafficking and amyloid β generation. Sullivan SE, Dillon GM, Sullivan JM, Ho A. J Biol Chem 289 15374-15383 (2014)
  16. Domain orientation in the N-Terminal PDZ tandem from PSD-95 is maintained in the full-length protein. McCann JJ, Zheng L, Chiantia S, Bowen ME. Structure 19 810-820 (2011)
  17. Intracellular trafficking of the amyloid β-protein precursor (APP) regulated by novel function of X11-like. Saito Y, Akiyama M, Araki Y, Sumioka A, Shiono M, Taru H, Nakaya T, Yamamoto T, Suzuki T. PLoS One 6 e22108 (2011)
  18. Specificity and autoregulation of Notch binding by tandem WW domains in suppressor of Deltex. Jennings MD, Blankley RT, Baron M, Golovanov AP, Avis JM. J Biol Chem 282 29032-29042 (2007)
  19. Extensions of PSD-95/discs large/ZO-1 (PDZ) domains influence lipid binding and membrane targeting of syntenin-1. Wawrzyniak AM, Vermeiren E, Zimmermann P, Ivarsson Y. FEBS Lett 586 1445-1451 (2012)
  20. Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms. Elkins JM, Gileadi C, Shrestha L, Phillips C, Wang J, Muniz JR, Doyle DA. Protein Sci 19 731-741 (2010)
  21. Interaction of Mint2 with TrkA is involved in regulation of nerve growth factor-induced neurite outgrowth. Zhang Y, Wang YG, Zhang Q, Liu XJ, Liu X, Jiao L, Zhu W, Zhang ZH, Zhao XL, He C. J Biol Chem 284 12469-12479 (2009)
  22. High-throughput screen for small molecule inhibitors of Mint1-PDZ domains. Chen X, Longgood JC, Michnoff C, Wei S, Frantz DE, Bezprozvanny L. Assay Drug Dev Technol 5 769-783 (2007)
  23. Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing. Matos MF, Xu Y, Dulubova I, Otwinowski Z, Richardson JM, Tomchick DR, Rizo J, Ho A. Proc Natl Acad Sci U S A 109 3802-3807 (2012)
  24. Binding free energy landscape of domain-peptide interactions. Staneva I, Wallin S. PLoS Comput Biol 7 e1002131 (2011)
  25. Solution structure of the first SRC homology 3 domain of human Nck2. Park S, Takeuchi K, Wagner G. J Biomol NMR 34 203-208 (2006)
  26. Structural insights into the PIP2 recognition by syntenin-1 PDZ domain. Sugi T, Oyama T, Morikawa K, Jingami H. Biochem Biophys Res Commun 366 373-378 (2008)
  27. Crystal structure of Src-like adaptor protein 2 reveals close association of SH3 and SH2 domains through β-sheet formation. Wybenga-Groot LE, McGlade CJ. Cell Signal 25 2702-2708 (2013)
  28. Open-closed motion of Mint2 regulates APP metabolism. Xie X, Yan X, Wang Z, Zhou H, Diao W, Zhou W, Long J, Shen Y. J Mol Cell Biol 5 48-56 (2013)
  29. News Scaffold proteins as dynamic switches. Zhang M. Nat Chem Biol 3 756-757 (2007)
  30. Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain. Zhao Y, Cushing PR, Smithson DC, Pellegrini M, Pletnev AA, Al-Ayyoubi S, Grassetti AV, Gerber SA, Guy RK, Madden DR. Biosci Rep 38 BSR20180231 (2018)
  31. Probing the Mint2 Protein-Protein Interaction Network Relevant to the Pathophysiology of Alzheimer's Disease. Jensen TMT, Albertsen L, Bartling CRO, Haugaard-Kedström LM, Strømgaard K. Chembiochem (2018)
  32. LIN-10 can promote LET-23 EGFR signaling and trafficking independently of LIN-2 and LIN-7. Gauthier KD, Rocheleau CE. Mol Biol Cell 32 788-799 (2021)
  33. News The double (strand break) life of Par-3. Lees-Miller SP. Nat Cell Biol 9 363-365 (2007)
  34. X11 and X11-like proteins regulate the level of extrasynaptic glutamate receptors. Motodate R, Saito H, Sobu Y, Hata S, Saito Y, Nakaya T, Suzuki T. J Neurochem 148 480-498 (2019)
  35. Interrogation and validation of the interactome of neuronal Munc18-interacting Mint proteins with AlphaFold2. Weeratunga S, Gormal RS, Liu M, Eldershaw D, Livingstone EK, Malapaka A, Wallis TP, Bademosi AT, Jiang A, Healy MD, Meunier FA, Collins BM. J Biol Chem 300 105541 (2024)
  36. The binding affinity of PTPN13's tandem PDZ2/3 domain is allosterically modulated. Dicks M, Kock G, Kohl B, Zhong X, Pütz S, Heumann R, Erdmann KS, Stoll R. BMC Mol Cell Biol 20 23 (2019)
  37. Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity. Genera M, Colcombet-Cazenave B, Croitoru A, Raynal B, Mechaly A, Caillet J, Haouz A, Wolff N, Caillet-Saguy C. Front Mol Biosci 10 1192621 (2023)
  38. The Chlamydia trachomatis Protease CPAF Contains a Cryptic PDZ-Like Domain with Similarity to Human Cell Polarity and Tight Junction PDZ-Containing Proteins. Maksimchuk KR, Alser KA, Mou R, Valdivia RH, McCafferty DG. PLoS One 11 e0147233 (2016)
  39. Understanding the molecular basis of folding cooperativity through a comparative analysis of a multidomain protein and its isolated domains. Santorelli D, Marcocci L, Pennacchietti V, Nardella C, Diop A, Pietrangeli P, Pagano L, Toto A, Malagrinò F, Gianni S. J Biol Chem 299 102983 (2023)


Quick links