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Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ECDKWCS

Source organisms:
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. ANTIBODY 2F5 (LIGHT CHAIN)
  2. ANTIBODY 2F5 (HEAVY CHAIN)
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. ANTIBODY 2F5 (LIGHT CHAIN)
  2. ANTIBODY 2F5 (HEAVY CHAIN)
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. ANTIBODY 2F5 (LIGHT CHAIN)
  2. ANTIBODY 2F5 (HEAVY CHAIN)
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. ANTIBODY 2F5 (LIGHT CHAIN)
  2. ANTIBODY 2F5 (HEAVY CHAIN)
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. ANTIBODY 2F5 (LIGHT CHAIN)
  2. ANTIBODY 2F5 (HEAVY CHAIN)
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. ANTIBODY 2F5 (LIGHT CHAIN)
  2. ANTIBODY 2F5 (HEAVY CHAIN)
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. ANTIBODY 2F5 (LIGHT CHAIN)
  2. ANTIBODY 2F5 (HEAVY CHAIN)

Structure domain

CATH CATH domain
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. ANTIBODY 2F5 (LIGHT CHAIN)
  2. ANTIBODY 2F5 (HEAVY CHAIN)
The deposited structure of PDB entry 1u8p contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in ANTIBODY 2F5 (LIGHT CHAIN). Showing 2 copies in chain A.
The deposited structure of PDB entry 1u8p contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in ANTIBODY 2F5 (HEAVY CHAIN). Showing 2 copies in chain B.
SCOP SCOP annotations
48942
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: Immunoglobulin
Occurring in:
  1. ANTIBODY 2F5 (LIGHT CHAIN)
  2. ANTIBODY 2F5 (HEAVY CHAIN)
The deposited structure of PDB entry 1u8p contains 1 copy of SCOP domain 48942 (C1 set domains (antibody constant domain-like)) in ANTIBODY 2F5 (LIGHT CHAIN). Showing 1 copy in chain A.
The deposited structure of PDB entry 1u8p contains 1 copy of SCOP domain 48942 (C1 set domains (antibody constant domain-like)) in ANTIBODY 2F5 (HEAVY CHAIN). Showing 1 copy in chain B.
48727
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: Immunoglobulin
Occurring in:
  1. ANTIBODY 2F5 (LIGHT CHAIN)
  2. ANTIBODY 2F5 (HEAVY CHAIN)
The deposited structure of PDB entry 1u8p contains 1 copy of SCOP domain 48727 (V set domains (antibody variable domain-like)) in ANTIBODY 2F5 (LIGHT CHAIN). Showing 1 copy in chain A.
The deposited structure of PDB entry 1u8p contains 1 copy of SCOP domain 48727 (V set domains (antibody variable domain-like)) in ANTIBODY 2F5 (HEAVY CHAIN). Showing 1 copy in chain B.

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