EC 1.12.2.1: Cytochrome-c3 hydrogenase
Reaction catalysed:
H(2) + 2 ferricytochrome c3 = 2 H(+) + 2 ferrocytochrome c3
Systematic name:
Hydrogen:ferricytochrome-c3 oxidoreductase
Alternative Name(s):
- Cytochrome c3 reductase
- Cytochrome hydrogenase
- H(2):ferricytochrome c3 oxidoreductase
- Hydrogenase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 1ubh contains 1 copy of Pfam domain PF14720 (NiFe/NiFeSe hydrogenase small subunit C-terminal) in Periplasmic [NiFe] hydrogenase small subunit. Showing 1 copy in chain A [auth S].](https://www.ebi.ac.uk/pdbe/static/entry/1ubh_1_S_Pfam_PF14720_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ubh</span> contains 1 copy of Pfam domain <span class='highlight'>PF14720 (NiFe/NiFeSe hydrogenase small subunit C-terminal)</span> in <span class='highlight'>Periplasmic [NiFe] hydrogenase small subunit</span>. Showing 1 copy in chain <span class='highlight'>A [auth S]</span>.")
![The deposited structure of PDB entry 1ubh contains 1 copy of Pfam domain PF01058 (NADH ubiquinone oxidoreductase, 20 Kd subunit) in Periplasmic [NiFe] hydrogenase small subunit. Showing 1 copy in chain A [auth S].](https://www.ebi.ac.uk/pdbe/static/entry/1ubh_1_S_Pfam_PF01058_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ubh</span> contains 1 copy of Pfam domain <span class='highlight'>PF01058 (NADH ubiquinone oxidoreductase, 20 Kd subunit)</span> in <span class='highlight'>Periplasmic [NiFe] hydrogenase small subunit</span>. Showing 1 copy in chain <span class='highlight'>A [auth S]</span>.")
![The deposited structure of PDB entry 1ubh contains 1 copy of Pfam domain PF00374 (Nickel-dependent hydrogenase) in Periplasmic [NiFe] hydrogenase large subunit. Showing 1 copy in chain B [auth L].](https://www.ebi.ac.uk/pdbe/static/entry/1ubh_2_L_Pfam_PF00374_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ubh</span> contains 1 copy of Pfam domain <span class='highlight'>PF00374 (Nickel-dependent hydrogenase)</span> in <span class='highlight'>Periplasmic [NiFe] hydrogenase large subunit</span>. Showing 1 copy in chain <span class='highlight'>B [auth L]</span>.")
InterPro annotations
IPR018194
Domain description:
Nickel-dependent hydrogenase, large subunit, nickel binding site
Occurring in:
Occurring in:
IPR037148
Domain description:
[NiFe]-hydrogenase, small subunit, C-terminal domain superfamily
Occurring in:
Occurring in:
IPR037024
Domain description:
[NiFe]-hydrogenase, small subunit, N-terminal domain superfamily
Occurring in:
Occurring in:
Structure domains
CATH domains
4.10.480.10
Class:
Few Secondary Structures
Architecture:
Irregular
Topology:
Cytochrome-c3 Hydrogenase; Chain A, domain 2
Homology:
Cytochrome-c3 hydrogenase, C-terminal domain
Occurring in:
![The deposited structure of PDB entry 1ubh contains 1 copy of CATH domain 4.10.480.10 (Cytochrome-c3 Hydrogenase; Chain A, domain 2) in Periplasmic [NiFe] hydrogenase small subunit. Showing 1 copy in chain A [auth S].](https://www.ebi.ac.uk/pdbe/static/entry/1ubh_1_S_CATH_4.10.480.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ubh</span> contains 1 copy of CATH domain <span class='highlight'>4.10.480.10 (Cytochrome-c3 Hydrogenase; Chain A, domain 2)</span> in <span class='highlight'>Periplasmic [NiFe] hydrogenase small subunit</span>. Showing 1 copy in chain <span class='highlight'>A [auth S]</span>.")
3.40.50.700
Class:
Alpha Beta
Architecture:
3-Layer(aba) Sandwich
Topology:
Rossmann fold
Homology:
NADH:ubiquinone oxidoreductase-like, 20kDa subunit
Occurring in:
![The deposited structure of PDB entry 1ubh contains 1 copy of CATH domain 3.40.50.700 (Rossmann fold) in Periplasmic [NiFe] hydrogenase small subunit. Showing 1 copy in chain A [auth S].](https://www.ebi.ac.uk/pdbe/static/entry/1ubh_1_S_CATH_3.40.50.700_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ubh</span> contains 1 copy of CATH domain <span class='highlight'>3.40.50.700 (Rossmann fold)</span> in <span class='highlight'>Periplasmic [NiFe] hydrogenase small subunit</span>. Showing 1 copy in chain <span class='highlight'>A [auth S]</span>.")
![The deposited structure of PDB entry 1ubh contains 1 copy of CATH domain 1.10.645.10 (Cytochrome-c3 Hydrogenase; chain B) in Periplasmic [NiFe] hydrogenase large subunit. Showing 1 copy in chain B [auth L].](https://www.ebi.ac.uk/pdbe/static/entry/1ubh_2_L_CATH_1.10.645.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ubh</span> contains 1 copy of CATH domain <span class='highlight'>1.10.645.10 (Cytochrome-c3 Hydrogenase; chain B)</span> in <span class='highlight'>Periplasmic [NiFe] hydrogenase large subunit</span>. Showing 1 copy in chain <span class='highlight'>B [auth L]</span>.")
SCOP annotations![The deposited structure of PDB entry 1ubh contains 1 copy of SCOP domain 56771 (Nickel-iron hydrogenase, small subunit) in Periplasmic [NiFe] hydrogenase small subunit. Showing 1 copy in chain A [auth S].](https://www.ebi.ac.uk/pdbe/static/entry/1ubh_1_S_SCOP_56771_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ubh</span> contains 1 copy of SCOP domain <span class='highlight'>56771 (Nickel-iron hydrogenase, small subunit)</span> in <span class='highlight'>Periplasmic [NiFe] hydrogenase small subunit</span>. Showing 1 copy in chain <span class='highlight'>A [auth S]</span>.")
![The deposited structure of PDB entry 1ubh contains 1 copy of SCOP domain 56763 (Nickel-iron hydrogenase, large subunit) in Periplasmic [NiFe] hydrogenase large subunit. Showing 1 copy in chain B [auth L].](https://www.ebi.ac.uk/pdbe/static/entry/1ubh_2_L_SCOP_56763_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ubh</span> contains 1 copy of SCOP domain <span class='highlight'>56763 (Nickel-iron hydrogenase, large subunit)</span> in <span class='highlight'>Periplasmic [NiFe] hydrogenase large subunit</span>. Showing 1 copy in chain <span class='highlight'>B [auth L]</span>.")