Function and Biology

Mutants of RNase Sa

Source organism: Kitasatospora aureofaciens
Biochemical function: ribonuclease T1 activity
Biological process: not assigned
Cellular component: extracellular region

EC 4.6.1.24: Ribonuclease T(1)

Reaction catalysed:
(1a) (RNA) containing guanosine = (RNA fragment)-3'-guanosine-2',3'-cyclophosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA fragment)
Systematic name:
(RNA)-guanosine 5'-hydroxy-ribonucleotide-3'-(RNA fragment)-lyase (cyclicizing; (RNA fragment)-3'-guanosine-2',3'-cyclophosphate-forming and hydrolyzing)
Alternative Name(s):
  • Aspergillus oryzae ribonuclease
  • Binase
  • Guanyl-specific RNase
  • Guanyloribonuclease
  • RNase F(1)
  • RNase G
  • RNase N(1)
  • RNase N(2)
  • RNase Sa
  • RNase T(1)
  • Ribonuclease C2
  • Ribonuclease Ch
  • Ribonuclease F(1)
  • Ribonuclease N(1)
  • Ribonuclease N(3)
  • Ribonuclease PP1
  • Ribonuclease SA
  • Ribonuclease T1
  • Ribonuclease U(1)
  • Ribonuclease guaninenucleotido-2'-transferase (cyclizing)

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00545
Domain description: ribonuclease
Occurring in:
  1. Guanyl-specific ribonuclease Sa
The deposited structure of PDB entry 1ucl contains 2 copies of Pfam domain PF00545 (ribonuclease) in Guanyl-specific ribonuclease Sa. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000026
Domain description: Guanine-specific ribonuclease N1-like
Occurring in:
  1. Guanyl-specific ribonuclease Sa
IPR016191
Domain description: Ribonuclease/ribotoxin
Occurring in:
  1. Guanyl-specific ribonuclease Sa

Structure domain

CATH CATH domain
3.10.450.30
Class: Alpha Beta
Architecture: Roll
Topology: Nuclear Transport Factor 2; Chain: A,
Homology: Microbial ribonucleases
Occurring in:
  1. Guanyl-specific ribonuclease Sa
The deposited structure of PDB entry 1ucl contains 2 copies of CATH domain 3.10.450.30 (Nuclear Transport Factor 2; Chain: A,) in Guanyl-specific ribonuclease Sa. Showing 1 copy in chain A.
SCOP SCOP annotation
81307
Class: Alpha and beta proteins (a+b)
Fold: Microbial ribonucleases
Superfamily: Microbial ribonucleases
Occurring in:
  1. Guanyl-specific ribonuclease Sa
The deposited structure of PDB entry 1ucl contains 2 copies of SCOP domain 81307 (Bacterial ribonucleases) in Guanyl-specific ribonuclease Sa. Showing 1 copy in chain A.