Function and Biology

Crystal Structure of STAM2 SH3 domain in complex with a UBPY-derived peptide

Source organism: Mus musculus
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

EC 3.4.19.12: Ubiquitinyl hydrolase 1

Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Systematic name:
-
Alternative Name(s):
  • Ubiquitin C-terminal hydrolase
  • Ubiquitin carboxyl-terminal hydrolase
  • Ubiquitin thiolesterase
  • Yeast ubiquitin hydrolase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00018
Domain description: SH3 domain
Occurring in:
  1. Signal transducing adapter molecule 2
The deposited structure of PDB entry 1uj0 contains 1 copy of Pfam domain PF00018 (SH3 domain) in Signal transducing adapter molecule 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001452
Domain description: SH3 domain
Occurring in:
  1. Signal transducing adapter molecule 2
IPR036028
Domain description: SH3-like domain superfamily
Occurring in:
  1. Signal transducing adapter molecule 2
IPR035675
Domain description: STAM2, SH3 domain
Occurring in:
  1. Signal transducing adapter molecule 2

Structure domain

CATH CATH domain
2.30.30.40
Class: Mainly Beta
Architecture: Roll
Topology: SH3 type barrels.
Homology: SH3 Domains
Occurring in:
  1. Signal transducing adapter molecule 2
The deposited structure of PDB entry 1uj0 contains 1 copy of CATH domain 2.30.30.40 (SH3 type barrels.) in Signal transducing adapter molecule 2. Showing 1 copy in chain A.
SCOP SCOP annotation
50045
Class: All beta proteins
Fold: SH3-like barrel
Superfamily: SH3-domain
Occurring in:
  1. Signal transducing adapter molecule 2
The deposited structure of PDB entry 1uj0 contains 1 copy of SCOP domain 50045 (SH3-domain) in Signal transducing adapter molecule 2. Showing 1 copy in chain A.