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PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, S554A MUTANT WITH BOUND PEPTIDE LIGAND GLU-PHE-SER-PRO

Source organisms:
Biochemical function: oligopeptidase activity
Biological process: proteolysis
Cellular component: cytosol

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EC 3.4.21.26: Prolyl oligopeptidase

Reaction catalysed:
Hydrolysis of --Pro-|- and to a lesser extent --Ala-|- in oligopeptides.
Systematic name:
-
Alternative Name(s):
  • Endoprolylpeptidase
  • Post-proline cleaving enzyme
  • Post-proline endopeptidase
  • Proline endopeptidase
  • Proline-specific endopeptidase
  • Prolyl endopeptidase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00326
Domain description: Prolyl oligopeptidase family
Occurring in:
  1. Prolyl endopeptidase
The deposited structure of PDB entry 1uoq contains 1 copy of Pfam domain PF00326 (Prolyl oligopeptidase family) in Prolyl endopeptidase. Showing 1 copy in chain A.

PF02897
Domain description: Prolyl oligopeptidase, N-terminal beta-propeller domain
Occurring in:
  1. Prolyl endopeptidase
The deposited structure of PDB entry 1uoq contains 1 copy of Pfam domain PF02897 (Prolyl oligopeptidase, N-terminal beta-propeller domain) in Prolyl endopeptidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002470
Domain description: Peptidase S9A, prolyl oligopeptidase
Occurring in:
  1. Prolyl endopeptidase
IPR029058
Domain description: Alpha/Beta hydrolase fold
Occurring in:
  1. Prolyl endopeptidase
IPR001375
Domain description: Peptidase S9, prolyl oligopeptidase, catalytic domain
Occurring in:
  1. Prolyl endopeptidase
IPR023302
Domain description: Peptidase S9A, N-terminal domain
Occurring in:
  1. Prolyl endopeptidase

Structure domains

CATH CATH domains
3.40.50.1820
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: alpha/beta hydrolase
Occurring in:
  1. Prolyl endopeptidase
The deposited structure of PDB entry 1uoq contains 1 copy of CATH domain 3.40.50.1820 (Rossmann fold) in Prolyl endopeptidase. Showing 1 copy in chain A.
2.130.10.120
Class: Mainly Beta
Architecture: 7 Propeller
Topology: Methylamine Dehydrogenase; Chain H
Homology: Prolyl oligopeptidase, N-terminal domain
Occurring in:
  1. Prolyl endopeptidase
The deposited structure of PDB entry 1uoq contains 1 copy of CATH domain 2.130.10.120 (Methylamine Dehydrogenase; Chain H) in Prolyl endopeptidase. Showing 1 copy in chain A.
SCOP SCOP annotations
53496
Class: Alpha and beta proteins (a/b)
Fold: alpha/beta-Hydrolases
Superfamily: alpha/beta-Hydrolases
Occurring in:
  1. Prolyl endopeptidase
The deposited structure of PDB entry 1uoq contains 1 copy of SCOP domain 53496 (Prolyl oligopeptidase, C-terminal domain) in Prolyl endopeptidase. Showing 1 copy in chain A.
50994
Class: All beta proteins
Fold: 7-bladed beta-propeller
Superfamily: Peptidase/esterase 'gauge' domain
Occurring in:
  1. Prolyl endopeptidase
The deposited structure of PDB entry 1uoq contains 1 copy of SCOP domain 50994 (Prolyl oligopeptidase, N-terminal domain) in Prolyl endopeptidase. Showing 1 copy in chain A.

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