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Carboxyethylarginine synthase from Streptomyces clavuligerus

Source organism: Streptomyces clavuligerus
Biochemical function: flavin adenine dinucleotide binding
Biological process: valine biosynthetic process
Cellular component: acetolactate synthase complex

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EC 2.5.1.66: N(2)-(2-carboxyethyl)arginine synthase

Reaction catalysed:
D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L-arginine + phosphate
Systematic name:
Glyceraldehyde-3-phosphate:L-arginine N(2)-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming)
Alternative Name(s):
  • CEA synthetase
  • CEAS
  • Glyceraldehyde-3-phosphate:L-arginine 2-N-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming)
  • N(2)-(2-carboxyethyl)arginine synthetase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02775
Domain description: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
Occurring in:
  1. N(2)-(2-carboxyethyl)arginine synthase
The deposited structure of PDB entry 1upb contains 4 copies of Pfam domain PF02775 (Thiamine pyrophosphate enzyme, C-terminal TPP binding domain) in N(2)-(2-carboxyethyl)arginine synthase. Showing 1 copy in chain B.

PF00205
Domain description: Thiamine pyrophosphate enzyme, central domain
Occurring in:
  1. N(2)-(2-carboxyethyl)arginine synthase
The deposited structure of PDB entry 1upb contains 4 copies of Pfam domain PF00205 (Thiamine pyrophosphate enzyme, central domain) in N(2)-(2-carboxyethyl)arginine synthase. Showing 1 copy in chain B.

PF02776
Domain description: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
Occurring in:
  1. N(2)-(2-carboxyethyl)arginine synthase
The deposited structure of PDB entry 1upb contains 4 copies of Pfam domain PF02776 (Thiamine pyrophosphate enzyme, N-terminal TPP binding domain) in N(2)-(2-carboxyethyl)arginine synthase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR029061
Domain description: Thiamin diphosphate-binding fold
Occurring in:
  1. N(2)-(2-carboxyethyl)arginine synthase
IPR000399
Domain description: TPP-binding enzyme, conserved site
Occurring in:
  1. N(2)-(2-carboxyethyl)arginine synthase
IPR011766
Domain description: Thiamine pyrophosphate enzyme, TPP-binding
Occurring in:
  1. N(2)-(2-carboxyethyl)arginine synthase
IPR012000
Domain description: Thiamine pyrophosphate enzyme, central domain
Occurring in:
  1. N(2)-(2-carboxyethyl)arginine synthase
IPR029035
Domain description: DHS-like NAD/FAD-binding domain superfamily
Occurring in:
  1. N(2)-(2-carboxyethyl)arginine synthase
IPR045229
Domain description: Thiamine pyrophosphate enzyme
Occurring in:
  1. N(2)-(2-carboxyethyl)arginine synthase
IPR012001
Domain description: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain
Occurring in:
  1. N(2)-(2-carboxyethyl)arginine synthase

Structure domains

CATH CATH domains
3.40.50.970
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. N(2)-(2-carboxyethyl)arginine synthase
The deposited structure of PDB entry 1upb contains 8 copies of CATH domain 3.40.50.970 (Rossmann fold) in N(2)-(2-carboxyethyl)arginine synthase. Showing 2 copies in chain B.
3.40.50.1220
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: TPP-binding domain
Occurring in:
  1. N(2)-(2-carboxyethyl)arginine synthase
The deposited structure of PDB entry 1upb contains 4 copies of CATH domain 3.40.50.1220 (Rossmann fold) in N(2)-(2-carboxyethyl)arginine synthase. Showing 1 copy in chain B.
SCOP SCOP annotations
88749
Class: Alpha and beta proteins (a/b)
Fold: Thiamin diphosphate-binding fold (THDP-binding)
Superfamily: Thiamin diphosphate-binding fold (THDP-binding)
Occurring in:
  1. N(2)-(2-carboxyethyl)arginine synthase
The deposited structure of PDB entry 1upb contains 4 copies of SCOP domain 88749 (Pyruvate oxidase and decarboxylase PP module) in N(2)-(2-carboxyethyl)arginine synthase. Showing 1 copy in chain B.
52475
Class: Alpha and beta proteins (a/b)
Fold: DHS-like NAD/FAD-binding domain
Superfamily: DHS-like NAD/FAD-binding domain
Occurring in:
  1. N(2)-(2-carboxyethyl)arginine synthase
The deposited structure of PDB entry 1upb contains 4 copies of SCOP domain 52475 (Pyruvate oxidase and decarboxylase, middle domain) in N(2)-(2-carboxyethyl)arginine synthase. Showing 1 copy in chain B.
88724
Class: Alpha and beta proteins (a/b)
Fold: Thiamin diphosphate-binding fold (THDP-binding)
Superfamily: Thiamin diphosphate-binding fold (THDP-binding)
Occurring in:
  1. N(2)-(2-carboxyethyl)arginine synthase
The deposited structure of PDB entry 1upb contains 4 copies of SCOP domain 88724 (Pyruvate oxidase and decarboxylase Pyr module) in N(2)-(2-carboxyethyl)arginine synthase. Showing 1 copy in chain B.

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