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The structure of echovirus type 12 bound to a two-domain fragment of its cellular attachment protein decay-accelerating factor (CD 55).

Bhella D, Goodfellow IG, Roversi P, Pettigrew D, Chaudhry Y, Evans DJ, Lea SM
J Biol Chem 279 8325-32 (2004)
Cited: 23 times
EuropePMC logo PMID: 14634014

Abstract

Echovirus type 12 (EV12), an Enterovirus of the Picornaviridae family, uses the complement regulator decay-accelerating factor (DAF, CD55) as a cellular receptor. We have calculated a three-dimensional reconstruction of EV12 bound to a fragment of DAF consisting of short consensus repeat domains 3 and 4 from cryo-negative stain electron microscopy data (EMD code 1057). This shows that, as for an earlier reconstruction of the related echovirus type 7 bound to DAF, attachment is not within the viral canyon but occurs close to the 2-fold symmetry axes. Despite this general similarity our reconstruction reveals a receptor interaction that is quite different from that observed for EV7. Fitting of the crystallographic co-ordinates for DAF(34) and EV11 into the reconstruction shows a close agreement between the crystal structure of the receptor fragment and the density for the virus-bound receptor, allowing unambiguous positioning of the receptor with respect to the virion (PDB code 1UPN). Our finding that the mode of virus-receptor interaction in EV12 is distinct from that seen for EV7 raises interesting questions regarding the evolution and biological significance of the DAF binding phenotype in these viruses.

Articles - 1upn mentioned but not cited (4)

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  2. Improved metrics for comparing structures of macromolecular assemblies determined by 3D electron-microscopy. Joseph AP, Lagerstedt I, Patwardhan A, Topf M, Winn M. J Struct Biol 199 12-26 (2017)
  3. The structure of echovirus type 12 bound to a two-domain fragment of its cellular attachment protein decay-accelerating factor (CD 55). Bhella D, Goodfellow IG, Roversi P, Pettigrew D, Chaudhry Y, Evans DJ, Lea SM. J Biol Chem 279 8325-8332 (2004)
  4. Switching of Receptor Binding Poses between Closely Related Enteroviruses. Zhou D, Qin L, Duyvesteyn HME, Zhao Y, Lin TY, Fry EE, Ren J, Huang KA, Stuart DI. Viruses 14 2625 (2022)


Reviews citing this publication (1)

  1. Blood Groups in Infection and Host Susceptibility. Cooling L. Clin Microbiol Rev 28 801-870 (2015)

Articles citing this publication (18)

  1. Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN. Pokidysheva E, Zhang Y, Battisti AJ, Bator-Kelly CM, Chipman PR, Xiao C, Gregorio GG, Hendrickson WA, Kuhn RJ, Rossmann MG. Cell 124 485-493 (2006)
  2. Distinguishing molecular features and clinical characteristics of a putative new rhinovirus species, human rhinovirus C (HRV C). McErlean P, Shackelton LA, Andrews E, Webster DR, Lambert SB, Nissen MD, Sloots TP, Mackay IM. PLoS One 3 e1847 (2008)
  3. Interaction with coxsackievirus and adenovirus receptor, but not with decay-accelerating factor (DAF), induces A-particle formation in a DAF-binding coxsackievirus B3 isolate. Milstone AM, Petrella J, Sanchez MD, Mahmud M, Whitbeck JC, Bergelson JM. J Virol 79 655-660 (2005)
  4. Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B. Zhao X, Zhang G, Liu S, Chen X, Peng R, Dai L, Qu X, Li S, Song H, Gao Z, Yuan P, Liu Z, Li C, Shang Z, Li Y, Zhang M, Qi J, Wang H, Du N, Wu Y, Bi Y, Gao S, Shi Y, Yan J, Zhang Y, Xie Z, Wei W, Gao GF. Cell 177 1553-1565.e16 (2019)
  5. The crystal structure of coxsackievirus A21 and its interaction with ICAM-1. Xiao C, Bator-Kelly CM, Rieder E, Chipman PR, Craig A, Kuhn RJ, Wimmer E, Rossmann MG. Structure 13 1019-1033 (2005)
  6. Inhibition of coxsackie B virus infection by soluble forms of its receptors: binding affinities, altered particle formation, and competition with cellular receptors. Goodfellow IG, Evans DJ, Blom AM, Kerrigan D, Miners JS, Morgan BP, Spiller OB. J Virol 79 12016-12024 (2005)
  7. Genome-scale detection of positive selection in nine primates predicts human-virus evolutionary conflicts. van der Lee R, Wiel L, van Dam TJP, Huynen MA. Nucleic Acids Res 45 10634-10648 (2017)
  8. The crystal structure of a coxsackievirus B3-RD variant and a refined 9-angstrom cryo-electron microscopy reconstruction of the virus complexed with decay-accelerating factor (DAF) provide a new footprint of DAF on the virus surface. Yoder JD, Cifuente JO, Pan J, Bergelson JM, Hafenstein S. J Virol 86 12571-12581 (2012)
  9. Interaction of alphaVbeta3 and alphaVbeta6 integrins with human parechovirus 1. Seitsonen J, Susi P, Heikkilä O, Sinkovits RS, Laurinmäki P, Hyypiä T, Butcher SJ. J Virol 84 8509-8519 (2010)
  10. Interaction of decay-accelerating factor with coxsackievirus B3. Hafenstein S, Bowman VD, Chipman PR, Bator Kelly CM, Lin F, Medof ME, Rossmann MG. J Virol 81 12927-12935 (2007)
  11. Structure-based mapping of DAF active site residues that accelerate the decay of C3 convertases. Kuttner-Kondo L, Hourcade DE, Anderson VE, Muqim N, Mitchell L, Soares DC, Barlow PN, Medof ME. J Biol Chem 282 18552-18562 (2007)
  12. Enhanced cellular receptor usage by a bioselected variant of coxsackievirus a21. Johansson ES, Xing L, Cheng RH, Shafren DR. J Virol 78 12603-12612 (2004)
  13. Neutralization of a common cold virus by concatemers of the third ligand binding module of the VLDL-receptor strongly depends on the number of modules. Moser R, Snyers L, Wruss J, Angulo J, Peters H, Peters T, Blaas D. Virology 338 259-269 (2005)
  14. Structures of Echovirus 30 in complex with its receptors inform a rational prediction for enterovirus receptor usage. Wang K, Zhu L, Sun Y, Li M, Zhao X, Cui L, Zhang L, Gao GF, Zhai W, Zhu F, Rao Z, Wang X. Nat Commun 11 4421 (2020)
  15. Molecular determinants of disease in coxsackievirus B1 murine infection. Cifuente JO, Ferrer MF, Jaquenod de Giusti C, Song WC, Romanowski V, Hafenstein SL, Gómez RM. J Med Virol 83 1571-1581 (2011)
  16. The random-model method enables ab initio 3D reconstruction of asymmetric particles and determination of particle symmetry. Sanz-García E, Stewart AB, Belnap DM. J Struct Biol 171 216-222 (2010)
  17. Two clusters of mutations map distinct receptor-binding sites of echovirus 11 for the decay-accelerating factor (CD55) and for canyon-binding receptors. Rezaikin AV, Novoselov AV, Sergeev AG, Fadeyev FA, Lebedev SV. Virus Res 145 74-79 (2009)
  18. Hsp70 Is a Potential Therapeutic Target for Echovirus 9 Infection. Wang Y, Zhang H, Ma D, Deng X, Wu D, Li F, Wu Q, Liu H, Wang J. Front Mol Biosci 7 146 (2020)


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