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Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats

Source organism: Homo sapiens
Biochemical function: calcium ion binding
Biological process: cell adhesion
Cellular component: extracellular region

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF02412
Domain description: Thrombospondin type 3 repeat
Occurring in:
  1. Thrombospondin-1
The deposited structure of PDB entry 1ux6 contains 4 copies of Pfam domain PF02412 (Thrombospondin type 3 repeat) in Thrombospondin-1. Showing 4 copies in chain A.

PF05735
Domain description: Thrombospondin C-terminal region
Occurring in:
  1. Thrombospondin-1
The deposited structure of PDB entry 1ux6 contains 1 copy of Pfam domain PF05735 (Thrombospondin C-terminal region) in Thrombospondin-1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003367
Domain description: Thrombospondin, type 3-like repeat
Occurring in:
  1. Thrombospondin-1
IPR008859
Domain description: Thrombospondin, C-terminal
Occurring in:
  1. Thrombospondin-1
IPR017897
Domain description: Thrombospondin, type 3 repeat
Occurring in:
  1. Thrombospondin-1
IPR028974
Domain description: TSP type-3 repeat
Occurring in:
  1. Thrombospondin-1
IPR013320
Domain description: Concanavalin A-like lectin/glucanase domain superfamily
Occurring in:
  1. Thrombospondin-1

Structure domains

CATH CATH domains
2.60.120.200
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Jelly Rolls
Occurring in:
  1. Thrombospondin-1
The deposited structure of PDB entry 1ux6 contains 1 copy of CATH domain 2.60.120.200 (Jelly Rolls) in Thrombospondin-1. Showing 1 copy in chain A.
4.10.1080.10
Class: Few Secondary Structures
Architecture: Irregular
Topology: TSP type-3 repeat
Homology: TSP type-3 repeat
Occurring in:
  1. Thrombospondin-1
The deposited structure of PDB entry 1ux6 contains 1 copy of CATH domain 4.10.1080.10 (TSP type-3 repeat) in Thrombospondin-1. Showing 1 copy in chain A.
SCOP SCOP annotations
101643
Class: All beta proteins
Fold: Concanavalin A-like lectins/glucanases
Superfamily: Concanavalin A-like lectins/glucanases
Occurring in:
  1. Thrombospondin-1
The deposited structure of PDB entry 1ux6 contains 1 copy of SCOP domain 101643 (Thrombospondin C-terminal domain) in Thrombospondin-1. Showing 1 copy in chain A.
103648
Class: Small proteins
Fold: TSP type-3 repeat
Superfamily: TSP type-3 repeat
Occurring in:
  1. Thrombospondin-1
The deposited structure of PDB entry 1ux6 contains 1 copy of SCOP domain 103648 (TSP type-3 repeat) in Thrombospondin-1. Showing 1 copy in chain A.

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