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Crystal structure of isocitrate dehydrogenase from Aeropyrum pernix

Source organism: Aeropyrum pernix
Biochemical function: NAD binding
Biological process: tricarboxylic acid cycle
Cellular component: not assigned

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EC 1.1.1.42: Isocitrate dehydrogenase (NADP(+))

Reaction catalysed:
(1a) isocitrate + NADP(+) = 2-oxalosuccinate + NADPH
Systematic name:
Isocitrate:NADP(+) oxidoreductase (decarboxylating)
Alternative Name(s):
  • Dual-cofactor-specific isocitrate dehydrogenase
  • IDH
  • IDP
  • IDP1
  • IDP2
  • IDP3
  • Isocitrate (NADP) dehydrogenase
  • Isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase
  • Isocitrate dehydrogenase (NADP)
  • Isocitrate dehydrogenase (NADP-dependent)
  • NADP isocitric dehydrogenase
  • NADP(+)-ICDH
  • NADP(+)-IDH
  • NADP(+)-linked isocitrate dehydrogenase
  • NADP-dependent isocitrate dehydrogenase
  • NADP-dependent isocitric dehydrogenase
  • NADP-linked isocitrate dehydrogenase
  • NADP-specific isocitrate dehydrogenase
  • Oxalosuccinate decarboxylase
  • Oxalsuccinic decarboxylase
  • Triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00180
Domain description: Isocitrate/isopropylmalate dehydrogenase
Occurring in:
  1. isocitrate dehydrogenase (NADP(+))
The deposited structure of PDB entry 1v94 contains 2 copies of Pfam domain PF00180 (Isocitrate/isopropylmalate dehydrogenase) in isocitrate dehydrogenase (NADP(+)). Showing 1 copy in chain A.

InterPro InterPro annotations
IPR024084
Domain description: Isopropylmalate dehydrogenase-like domain
Occurring in:
  1. isocitrate dehydrogenase (NADP(+))
IPR019818
Domain description: Isocitrate/isopropylmalate dehydrogenase, conserved site
Occurring in:
  1. isocitrate dehydrogenase (NADP(+))
IPR004439
Domain description: Isocitrate dehydrogenase NADP-dependent, dimeric, prokaryotic
Occurring in:
  1. isocitrate dehydrogenase (NADP(+))

Structure domain

CATH CATH domain
3.40.718.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Isopropylmalate Dehydrogenase
Homology: Isopropylmalate Dehydrogenase
Occurring in:
  1. isocitrate dehydrogenase (NADP(+))
The deposited structure of PDB entry 1v94 contains 2 copies of CATH domain 3.40.718.10 (Isopropylmalate Dehydrogenase) in isocitrate dehydrogenase (NADP(+)). Showing 1 copy in chain A.

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