› › Function and Biology

Pyruvate Phosphate Dikinase with bound Mg-PEP from Maize

Source organism: Zea mays
Biochemical function: pyruvate, phosphate dikinase activity
Biological process: phosphorylation
Cellular component: chloroplast

Quick links

EC 2.7.9.1: Pyruvate, phosphate dikinase

Reaction catalysed:
ATP + pyruvate + phosphate = AMP + phosphoenolpyruvate + diphosphate
Systematic name:
ATP:pyruvate, phosphate phosphotransferase
Alternative Name(s):
  • Orthophosphate dikinase pyruvate
  • PPDK
  • Pyruvate, P(i) dikinase
  • Pyruvate,orthophosphate dikinase
  • Pyruvate,phosphate dikinase
  • Pyruvate-inorganic phosphate dikinase
  • Pyruvate-phosphate dikinase
  • Pyruvate-phosphate dikinase (phosphorylating)
  • Pyruvate-phosphate ligase
  • Pyruvic-phosphate dikinase
  • Pyruvic-phosphate ligase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01326
Domain description: Pyruvate phosphate dikinase, AMP/ATP-binding domain
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic
The deposited structure of PDB entry 1vbh contains 3 copies of Pfam domain PF01326 (Pyruvate phosphate dikinase, AMP/ATP-binding domain) in Pyruvate, phosphate dikinase 1, chloroplastic. Showing 3 copies in chain A.

PF02896
Domain description: PEP-utilising enzyme, PEP-binding domain
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic
The deposited structure of PDB entry 1vbh contains 1 copy of Pfam domain PF02896 (PEP-utilising enzyme, PEP-binding domain) in Pyruvate, phosphate dikinase 1, chloroplastic. Showing 1 copy in chain A.

PF00391
Domain description: PEP-utilising enzyme, mobile domain
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic
The deposited structure of PDB entry 1vbh contains 1 copy of Pfam domain PF00391 (PEP-utilising enzyme, mobile domain) in Pyruvate, phosphate dikinase 1, chloroplastic. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002192
Domain description: Pyruvate phosphate dikinase, AMP/ATP-binding
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic
IPR010121
Domain description: Pyruvate, phosphate dikinase
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic
IPR023151
Domain description: PEP-utilising enzyme, conserved site
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic
IPR040442
Domain description: Pyruvate kinase-like domain superfamily
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic
IPR015813
Domain description: Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic
IPR000121
Domain description: PEP-utilising enzyme, C-terminal
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic
IPR018274
Domain description: PEP-utilising enzyme, active site
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic
IPR008279
Domain description: PEP-utilising enzyme, mobile domain
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic
IPR036637
Domain description: Phosphohistidine domain superfamily
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic
IPR013815
Domain description: ATP-grasp fold, subdomain 1
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic

Structure domains

CATH CATH domains
1.10.189.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Pyruvate Phosphate di-kinase; domain 2
Homology: Pyruvate Phosphate Dikinase, domain 2
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic
The deposited structure of PDB entry 1vbh contains 1 copy of CATH domain 1.10.189.10 (Pyruvate Phosphate di-kinase; domain 2) in Pyruvate, phosphate dikinase 1, chloroplastic. Showing 1 copy in chain A.
3.30.1490.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Dna Ligase; domain 1
Homology: ATP-grasp fold, A domain
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic
The deposited structure of PDB entry 1vbh contains 1 copy of CATH domain 3.30.1490.20 (Dna Ligase; domain 1) in Pyruvate, phosphate dikinase 1, chloroplastic. Showing 1 copy in chain A.
3.20.20.60
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Phosphoenolpyruvate-binding domains
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic
The deposited structure of PDB entry 1vbh contains 1 copy of CATH domain 3.20.20.60 (TIM Barrel) in Pyruvate, phosphate dikinase 1, chloroplastic. Showing 1 copy in chain A.
3.50.30.10
Class: Alpha Beta
Architecture: 3-Layer(bba) Sandwich
Topology: Glucose Oxidase; domain 1
Homology: Phosphohistidine domain
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic
The deposited structure of PDB entry 1vbh contains 1 copy of CATH domain 3.50.30.10 (Glucose Oxidase; domain 1) in Pyruvate, phosphate dikinase 1, chloroplastic. Showing 1 copy in chain A.
3.30.470.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: D-amino Acid Aminotransferase; Chain A, domain 1
Homology: ATP-grasp fold, B domain
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic
The deposited structure of PDB entry 1vbh contains 1 copy of CATH domain 3.30.470.20 (D-amino Acid Aminotransferase; Chain A, domain 1) in Pyruvate, phosphate dikinase 1, chloroplastic. Showing 1 copy in chain A.
1.20.80.30
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Acyl-CoA Binding Protein
Homology: Acyl-CoA Binding Protein
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic
The deposited structure of PDB entry 1vbh contains 1 copy of CATH domain 1.20.80.30 (Acyl-CoA Binding Protein) in Pyruvate, phosphate dikinase 1, chloroplastic. Showing 1 copy in chain A.
SCOP SCOP annotations
51629
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: Phosphoenolpyruvate/pyruvate domain
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic
The deposited structure of PDB entry 1vbh contains 1 copy of SCOP domain 51629 (Pyruvate phosphate dikinase, C-terminal domain) in Pyruvate, phosphate dikinase 1, chloroplastic. Showing 1 copy in chain A.
52010
Class: Alpha and beta proteins (a/b)
Fold: The "swivelling" beta/beta/alpha domain
Superfamily: Phosphohistidine domain
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic
The deposited structure of PDB entry 1vbh contains 1 copy of SCOP domain 52010 (Pyruvate phosphate dikinase, central domain) in Pyruvate, phosphate dikinase 1, chloroplastic. Showing 1 copy in chain A.
56085
Class: Alpha and beta proteins (a+b)
Fold: ATP-grasp
Superfamily: Glutathione synthetase ATP-binding domain-like
Occurring in:
  1. Pyruvate, phosphate dikinase 1, chloroplastic
The deposited structure of PDB entry 1vbh contains 1 copy of SCOP domain 56085 (Pyruvate phosphate dikinase, N-terminal domain) in Pyruvate, phosphate dikinase 1, chloroplastic. Showing 1 copy in chain A.

Quick links