EC 2.7.9.1: Pyruvate, phosphate dikinase
Reaction catalysed:
ATP + pyruvate + phosphate = AMP + phosphoenolpyruvate + diphosphate
Systematic name:
ATP:pyruvate, phosphate phosphotransferase
Alternative Name(s):
- Orthophosphate dikinase pyruvate
- PPDK
- Pyruvate, P(i) dikinase
- Pyruvate,orthophosphate dikinase
- Pyruvate,phosphate dikinase
- Pyruvate-inorganic phosphate dikinase
- Pyruvate-phosphate dikinase
- Pyruvate-phosphate dikinase (phosphorylating)
- Pyruvate-phosphate ligase
- Pyruvic-phosphate dikinase
- Pyruvic-phosphate ligase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
IPR015813
Domain description:
Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily
Occurring in:
Occurring in:
Structure domains
CATH domains
1.10.189.10
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Pyruvate Phosphate di-kinase; domain 2
Homology:
Pyruvate Phosphate Dikinase, domain 2
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1vbh</span> contains 1 copy of CATH domain <span class='highlight'>1.10.189.10 (Pyruvate Phosphate di-kinase; domain 2)</span> in <span class='highlight'>Pyruvate, phosphate dikinase 1, chloroplastic</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 1vbh contains 1 copy of CATH domain 1.10.189.10 (Pyruvate Phosphate di-kinase; domain 2) in Pyruvate, phosphate dikinase 1, chloroplastic. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1vbh_1_A_CATH_1.10.189.10_image-200x200.png)
3.30.1490.20
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Dna Ligase; domain 1
Homology:
ATP-grasp fold, A domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1vbh</span> contains 1 copy of CATH domain <span class='highlight'>3.30.1490.20 (Dna Ligase; domain 1)</span> in <span class='highlight'>Pyruvate, phosphate dikinase 1, chloroplastic</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 1vbh contains 1 copy of CATH domain 3.30.1490.20 (Dna Ligase; domain 1) in Pyruvate, phosphate dikinase 1, chloroplastic. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1vbh_1_A_CATH_3.30.1490.20_image-200x200.png)
3.20.20.60
Class:
Alpha Beta
Architecture:
Alpha-Beta Barrel
Topology:
TIM Barrel
Homology:
Phosphoenolpyruvate-binding domains
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1vbh</span> contains 1 copy of CATH domain <span class='highlight'>3.20.20.60 (TIM Barrel)</span> in <span class='highlight'>Pyruvate, phosphate dikinase 1, chloroplastic</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 1vbh contains 1 copy of CATH domain 3.20.20.60 (TIM Barrel) in Pyruvate, phosphate dikinase 1, chloroplastic. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1vbh_1_A_CATH_3.20.20.60_image-200x200.png)
3.50.30.10
Class:
Alpha Beta
Architecture:
3-Layer(bba) Sandwich
Topology:
Glucose Oxidase; domain 1
Homology:
Phosphohistidine domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1vbh</span> contains 1 copy of CATH domain <span class='highlight'>3.50.30.10 (Glucose Oxidase; domain 1)</span> in <span class='highlight'>Pyruvate, phosphate dikinase 1, chloroplastic</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 1vbh contains 1 copy of CATH domain 3.50.30.10 (Glucose Oxidase; domain 1) in Pyruvate, phosphate dikinase 1, chloroplastic. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1vbh_1_A_CATH_3.50.30.10_image-200x200.png)
3.30.470.20
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
D-amino Acid Aminotransferase; Chain A, domain 1
Homology:
ATP-grasp fold, B domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1vbh</span> contains 1 copy of CATH domain <span class='highlight'>3.30.470.20 (D-amino Acid Aminotransferase; Chain A, domain 1)</span> in <span class='highlight'>Pyruvate, phosphate dikinase 1, chloroplastic</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 1vbh contains 1 copy of CATH domain 3.30.470.20 (D-amino Acid Aminotransferase; Chain A, domain 1) in Pyruvate, phosphate dikinase 1, chloroplastic. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1vbh_1_A_CATH_3.30.470.20_image-200x200.png)
SCOP annotations
51629
Class:
Alpha and beta proteins (a/b)
Fold:
TIM beta/alpha-barrel
Superfamily:
Phosphoenolpyruvate/pyruvate domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1vbh</span> contains 1 copy of SCOP domain <span class='highlight'>51629 (Pyruvate phosphate dikinase, C-terminal domain)</span> in <span class='highlight'>Pyruvate, phosphate dikinase 1, chloroplastic</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 1vbh contains 1 copy of SCOP domain 51629 (Pyruvate phosphate dikinase, C-terminal domain) in Pyruvate, phosphate dikinase 1, chloroplastic. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1vbh_1_A_SCOP_51629_image-200x200.png)
52010
Class:
Alpha and beta proteins (a/b)
Fold:
The "swivelling" beta/beta/alpha domain
Superfamily:
Phosphohistidine domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1vbh</span> contains 1 copy of SCOP domain <span class='highlight'>52010 (Pyruvate phosphate dikinase, central domain)</span> in <span class='highlight'>Pyruvate, phosphate dikinase 1, chloroplastic</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 1vbh contains 1 copy of SCOP domain 52010 (Pyruvate phosphate dikinase, central domain) in Pyruvate, phosphate dikinase 1, chloroplastic. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1vbh_1_A_SCOP_52010_image-200x200.png)
56085
Class:
Alpha and beta proteins (a+b)
Fold:
ATP-grasp
Superfamily:
Glutathione synthetase ATP-binding domain-like
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>1vbh</span> contains 1 copy of SCOP domain <span class='highlight'>56085 (Pyruvate phosphate dikinase, N-terminal domain)</span> in <span class='highlight'>Pyruvate, phosphate dikinase 1, chloroplastic</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 1vbh contains 1 copy of SCOP domain 56085 (Pyruvate phosphate dikinase, N-terminal domain) in Pyruvate, phosphate dikinase 1, chloroplastic. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1vbh_1_A_SCOP_56085_image-200x200.png)