› 1whl

Solution NMR

Solution structure of the 1st CAP-Gly domain in human cylindromatosis tumor suppressor CYLD

Released:
DOI: 10.2210/pdb1whl/pdb
PDB entry 1whl coloured by chain, ensemble of 20 models, front view.
PDB entry 1whl coloured by chain, ensemble of 20 models, side view.
PDB entry 1whl coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Saito K, Koshiba S, Inoue M, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-576229 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ubiquitin carboxyl-terminal hydrolase CYLD Chain: A
Molecule details ›
Chain: A
Length: 95 amino acids
Theoretical weight: 10.04 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9NQC7 (Residues: 125-206; Coverage: 9%)
Gene names: CYLD, CYLD1, HSPC057, KIAA0849
Sequence domains: CAP-Gly domain
Structure domains: CAP Gly-rich-like domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

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