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Crystal structure of PH1346 protein from Pyrococcus horikoshii

Source organism: Pyrococcus horikoshii
Biochemical function: ligase activity
Biological process: glutamine metabolic process
Cellular component: cytosol

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EC 6.3.5.2: GMP synthase (glutamine-hydrolyzing)

Reaction catalysed:
(1a) L-glutamine + H(2)O = L-glutamate + NH(4)(+)
Systematic name:
Xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)
Alternative Name(s):
  • GMP synthetase (glutamine-hydrolyzing)
  • Guanosine 5'-monophosphate synthetase
  • Guanosine monophosphate synthetase (glutamine-hydrolyzing)
  • Guanylate synthetase (glutamine-hydrolyzing)
  • Xanthosine 5'-phosphate amidotransferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00117
Domain description: Glutamine amidotransferase class-I
Occurring in:
  1. GMP synthase [glutamine-hydrolyzing] subunit A
The deposited structure of PDB entry 1wl8 contains 1 copy of Pfam domain PF00117 (Glutamine amidotransferase class-I) in GMP synthase [glutamine-hydrolyzing] subunit A. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004739
Domain description: GMP synthase, glutamine amidotransferase
Occurring in:
  1. GMP synthase [glutamine-hydrolyzing] subunit A
IPR029062
Domain description: Class I glutamine amidotransferase-like
Occurring in:
  1. GMP synthase [glutamine-hydrolyzing] subunit A
IPR017926
Domain description: Glutamine amidotransferase
Occurring in:
  1. GMP synthase [glutamine-hydrolyzing] subunit A
IPR023686
Domain description: GMP synthase (glutamine-hydrolyzing) subunit A
Occurring in:
  1. GMP synthase [glutamine-hydrolyzing] subunit A

Structure domain

CATH CATH domain
3.40.50.880
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. GMP synthase [glutamine-hydrolyzing] subunit A
The deposited structure of PDB entry 1wl8 contains 1 copy of CATH domain 3.40.50.880 (Rossmann fold) in GMP synthase [glutamine-hydrolyzing] subunit A. Showing 1 copy in chain A.
SCOP SCOP annotation
52318
Class: Alpha and beta proteins (a/b)
Fold: Flavodoxin-like
Superfamily: Class I glutamine amidotransferase-like
Occurring in:
  1. GMP synthase [glutamine-hydrolyzing] subunit A
The deposited structure of PDB entry 1wl8 contains 1 copy of SCOP domain 52318 (Class I glutamine amidotransferases (GAT)) in GMP synthase [glutamine-hydrolyzing] subunit A. Showing 1 copy in chain A.

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