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Structure of the tetrameric form of Human L-Xylulose Reductase

Source organism: Homo sapiens
Biochemical function: L-xylulose reductase (NADPH) activity
Biological process: positive regulation of reactive oxygen species metabolic process
Cellular component: extracellular exosome

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EC 1.1.1.10: L-xylulose reductase

Reaction catalysed:
Xylitol + NADP(+) = L-xylulose + NADPH
Systematic name:
Xylitol:NADP(+) 4-oxidoreductase (L-xylulose-forming)
Alternative Name(s):
  • Xylitol dehydrogenase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF13561
Domain description: Enoyl-(Acyl carrier protein) reductase
Occurring in:
  1. L-xylulose reductase
The deposited structure of PDB entry 1wnt contains 4 copies of Pfam domain PF13561 (Enoyl-(Acyl carrier protein) reductase) in L-xylulose reductase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002347
Domain description: Short-chain dehydrogenase/reductase SDR
Occurring in:
  1. L-xylulose reductase
IPR020904
Domain description: Short-chain dehydrogenase/reductase, conserved site
Occurring in:
  1. L-xylulose reductase
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. L-xylulose reductase

Structure domain

CATH CATH domain
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. L-xylulose reductase
The deposited structure of PDB entry 1wnt contains 4 copies of CATH domain 3.40.50.720 (Rossmann fold) in L-xylulose reductase. Showing 1 copy in chain A.
SCOP SCOP annotation
51751
Class: Alpha and beta proteins (a/b)
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Occurring in:
  1. L-xylulose reductase
The deposited structure of PDB entry 1wnt contains 4 copies of SCOP domain 51751 (Tyrosine-dependent oxidoreductases) in L-xylulose reductase. Showing 1 copy in chain A.

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