› 1wp8

X-ray diffraction
2.2Å resolution

crystal structure of Hendra Virus fusion core

Released:
DOI: 10.2210/pdb1wp8/pdb
PDB entry 1wp8 coloured by chain, front view.
PDB entry 1wp8 coloured by chain, side view.
PDB entry 1wp8 coloured by chain, top view.
Source organism: Henipavirus hendraense
Primary publication:
Crystal structures of Nipah and Hendra virus fusion core proteins.
Lou Z, Xu Y, Xiang K, Su N, Qin L, Li X, Gao GF, Bartlam M, Rao Z
OpenAccess logo FEBS J 273 4538-47 (2006)
PMID: 16972940

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131621 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fusion glycoprotein F1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 89 amino acids
Theoretical weight: 9.75 KDa
Source organism: Henipavirus hendraense
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O89342 (Residues: 137-178, 187-205; Coverage: 12%)
Gene name: F
Structure domains: YojJ-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BSRF BEAMLINE 3W1A
Spacegroup: P1
Unit cell:
a: 32.188Å b: 31.897Å c: 53.868Å
α: 86.33° β: 86.16° γ: 67.98°
R-values:
R R work R free
0.213 0.213 0.274
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Modes of paramyxovirus fusion: a Henipavirus perspective.
Lee et al. (2011)
7 more

4 mentions without citation

Inhibition of Nipah virus infection in vivo: targeting an early stage of paramyxovirus fusion activation during viral entry.
Porotto et al. (2010)
3 more