› 1wpg

X-ray diffraction
2.3Å resolution

Crystal structure of the SR CA2+-ATPase with MGF4

Released:
DOI: 10.2210/pdb1wpg/pdb
Model geometry
Fit model/data
Data not deposited
PDB entry 1wpg coloured by chain, front view.
PDB entry 1wpg coloured by chain, side view.
PDB entry 1wpg coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Lumenal gating mechanism revealed in calcium pump crystal structures with phosphate analogues.
Toyoshima C, Nomura H, Tsuda T
Nature 432 361-8 (2004)
PMID: 15448704

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137508 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 994 amino acids
Theoretical weight: 109.6 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P04191 (Residues: 1-993; Coverage: 99%)
  • Best match: P04191-2 (Residues: 1-994)
Gene name: ATP2A1
Sequence domains:
Structure domains:

Ligands and Environments

5 bound ligands:
Ligand MG 8 x MG
Ligand NA 4 x NA
Ligand MF4 4 x MF4
Ligand ADP 4 x ADP
Ligand TG1 4 x TG1
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P21
Unit cell:
a: 102.21Å b: 275.394Å c: 109.945Å
α: 90° β: 90.01° γ: 90°
R-values:
R R work R free
0.23 0.223 0.245

Quick links

Citations

47 review citations

P-type ATPases.
Palmgren et al. (2011)
46 more

51 mentions without citation

The Ca2+ pumps of the endoplasmic reticulum and Golgi apparatus.
Vandecaetsbeek et al. (2011)
50 more