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Solution structure of APETx1, a specific peptide inhibitor of human Ether-a-go-go-related gene potassium channels from the venom of the sea anemone Anthopleura elegantissima: a new fold for an HERG toxin

Source organism: Anthopleura elegantissima
Biochemical function: toxin activity
Biological process: defense response to bacterium
Cellular component: nematocyst

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF07936
Domain description: Potassium-channel blocking toxin
Occurring in:
  1. Kappa-actitoxin-Ael2a
The deposited structure of PDB entry 1wqk contains 1 copy of Pfam domain PF07936 (Potassium-channel blocking toxin) in Kappa-actitoxin-Ael2a. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR012414
Domain description: BDS potassium channel toxin
Occurring in:
  1. Kappa-actitoxin-Ael2a
IPR023355
Domain description: Myotoxin/Anemone neurotoxin domain superfamily
Occurring in:
  1. Kappa-actitoxin-Ael2a

Structure domain

CATH CATH domain
2.20.20.10
Class: Mainly Beta
Architecture: Single Sheet
Topology: Anthopleurin-A
Homology: Anthopleurin-A
Occurring in:
  1. Kappa-actitoxin-Ael2a
The deposited structure of PDB entry 1wqk contains 1 copy of CATH domain 2.20.20.10 (Anthopleurin-A) in Kappa-actitoxin-Ael2a. Showing 1 copy in chain A.

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