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Urate oxidase from aspergillus flavus complexed with uracil

Source organism: Aspergillus flavus
Biochemical function: oxidoreductase activity
Biological process: urate catabolic process
Cellular component: peroxisome

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EC 1.7.3.3: Factor independent urate hydroxylase

Reaction catalysed:
Urate + O(2) + H(2)O = 5-hydroxyisourate + H(2)O(2)
Systematic name:
Urate:oxygen oxidoreductase
Alternative Name(s):
  • Urate oxidase
  • Uric acid oxidase
  • Uricase
  • Uricase II

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01014
Domain description: Uricase
Occurring in:
  1. Uricase
The deposited structure of PDB entry 1ws3 contains 8 copies of Pfam domain PF01014 (Uricase) in Uricase. Showing 2 copies in chain C.

InterPro InterPro annotations
IPR002042
Domain description: Uricase
Occurring in:
  1. Uricase
IPR019842
Domain description: Uricase, conserved site
Occurring in:
  1. Uricase

Structure domain

CATH CATH domain
3.10.270.10
Class: Alpha Beta
Architecture: Roll
Topology: Urate Oxidase
Homology: Urate Oxidase;
Occurring in:
  1. Uricase
The deposited structure of PDB entry 1ws3 contains 4 copies of CATH domain 3.10.270.10 (Urate Oxidase) in Uricase. Showing 1 copy in chain C.
SCOP SCOP annotation
55633
Class: Alpha and beta proteins (a+b)
Fold: T-fold
Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like
Occurring in:
  1. Uricase
The deposited structure of PDB entry 1ws3 contains 8 copies of SCOP domain 55633 (Urate oxidase (uricase)) in Uricase. Showing 2 copies in chain C.

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