› › Function and Biology

crystal structure of human galactokinase complexed with MgAMPPNP and galactose

Source organism: Homo sapiens
Biochemical function: phosphotransferase activity, alcohol group as acceptor
Biological process: glycolytic process from galactose
Cellular component: extracellular exosome

Quick links

EC 2.7.1.6: Galactokinase

Reaction catalysed:
ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate
Systematic name:
ATP:alpha-D-galactose 1-phosphotransferase
Alternative Name(s):
  • ATP:D-galactose-1-phosphotransferase
  • Galactokinase (phosphorylating)

GO terms

Sequence families

Pfam Protein families (Pfam)
PF08544
Domain description: GHMP kinases C terminal
Occurring in:
  1. Galactokinase
The deposited structure of PDB entry 1wuu contains 4 copies of Pfam domain PF08544 (GHMP kinases C terminal) in Galactokinase. Showing 1 copy in chain A.

PF00288
Domain description: GHMP kinases N terminal domain
Occurring in:
  1. Galactokinase
The deposited structure of PDB entry 1wuu contains 4 copies of Pfam domain PF00288 (GHMP kinases N terminal domain) in Galactokinase. Showing 1 copy in chain A.

PF10509
Domain description: Galactokinase galactose-binding signature
Occurring in:
  1. Galactokinase
The deposited structure of PDB entry 1wuu contains 4 copies of Pfam domain PF10509 (Galactokinase galactose-binding signature) in Galactokinase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000705
Domain description: Galactokinase
Occurring in:
  1. Galactokinase
IPR036554
Domain description: GHMP kinase, C-terminal domain superfamily
Occurring in:
  1. Galactokinase
IPR013750
Domain description: GHMP kinase, C-terminal domain
Occurring in:
  1. Galactokinase
IPR006203
Domain description: GHMP kinase, ATP-binding, conserved site
Occurring in:
  1. Galactokinase
IPR006204
Domain description: GHMP kinase N-terminal domain
Occurring in:
  1. Galactokinase
IPR019741
Domain description: Galactokinase, conserved site
Occurring in:
  1. Galactokinase
IPR019539
Domain description: Galactokinase, N-terminal domain
Occurring in:
  1. Galactokinase
IPR020568
Domain description: Ribosomal protein uS5 domain 2-type superfamily
Occurring in:
  1. Galactokinase
IPR014721
Domain description: Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
Occurring in:
  1. Galactokinase
IPR006206
Domain description: Mevalonate/galactokinase
Occurring in:
  1. Galactokinase

Structure domains

CATH CATH domains
3.30.230.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Ribosomal Protein S5; domain 2
Homology: Ribosomal Protein S5; domain 2
Occurring in:
  1. Galactokinase
The deposited structure of PDB entry 1wuu contains 4 copies of CATH domain 3.30.230.10 (Ribosomal Protein S5; domain 2) in Galactokinase. Showing 1 copy in chain A.
3.30.70.890
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: GHMP kinase, C-terminal domain
Occurring in:
  1. Galactokinase
The deposited structure of PDB entry 1wuu contains 4 copies of CATH domain 3.30.70.890 (Alpha-Beta Plaits) in Galactokinase. Showing 1 copy in chain A.
SCOP SCOP annotations
103011
Class: Alpha and beta proteins (a+b)
Fold: Ferredoxin-like
Superfamily: GHMP Kinase, C-terminal domain
Occurring in:
  1. Galactokinase
The deposited structure of PDB entry 1wuu contains 4 copies of SCOP domain 103011 (Galactokinase) in Galactokinase. Showing 1 copy in chain A.
54232
Class: Alpha and beta proteins (a+b)
Fold: Ribosomal protein S5 domain 2-like
Superfamily: Ribosomal protein S5 domain 2-like
Occurring in:
  1. Galactokinase
The deposited structure of PDB entry 1wuu contains 4 copies of SCOP domain 54232 (GHMP Kinase, N-terminal domain) in Galactokinase. Showing 1 copy in chain A.

Quick links