› 1x0f

Solution NMR

Complex structure of the C-terminal RNA-binding domain of hnRNP D(AUF1) with telomeric DNA

Released:
DOI: 10.2210/pdb1x0f/pdb
PDB entry 1x0f coloured by chain, ensemble of 20 models, front view.
PDB entry 1x0f coloured by chain, ensemble of 20 models, side view.
PDB entry 1x0f coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of hnRNP D complexed with single-stranded telomere DNA and unfolding of the quadruplex by heterogeneous nuclear ribonucleoprotein D.
Enokizono Y, Konishi Y, Nagata K, Ouhashi K, Uesugi S, Ishikawa F, Katahira M
J Biol Chem 280 18862-70 (2005)
PMID: 15734733

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114782 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Heterogeneous nuclear ribonucleoprotein D0 Chain: A
Molecule details ›
Chain: A
Length: 79 amino acids
Theoretical weight: 9.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14103 (Residues: 181-259; Coverage: 22%)
Gene names: AUF1, HNRNPD, HNRPD
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits
5'-D(P*TP*AP*GP*G)-3' Chain: B
Molecule details ›
Chain: B
Length: 4 nucleotides
Theoretical weight: 1.23 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

20 review citations

The hnRNP family: insights into their role in health and disease.
Geuens et al. (2016)
19 more

4 mentions without citation

Characterization of epitranscriptome reader proteins experimentally and in silico: Current knowledge and future perspectives beyond the YTH domain.
Miller et al. (2023)
3 more